We have previously reported increased relative cerebral blood flow (rCBF) in the left globus pallidus of neuroleptic-naive schizophrenics. We have demonstrated that regional oxygen metabolism (rCMR02) is also increased in the left globus pallidus (15) and have replicated the rCBF finding in an additional 12 neuroleptic-naive patients and 20 controls. It is thought that increased rCBF and rCMR02 in the left globus pallidus reflect either increased number or increased activity of neurons projecting to the globus pallidus. We have proposed a model of left striato-pallidal hyperactivity in schizophrenia to account for the left globus pallidus finding and other behavioral evidence for right-side hemineglect-like phenomena. This model predicts that neuroleptic treatment will be associated with a relative decrease in rCBF and rCMR02 in the left globus pallidus. We also expect that neuroleptic treatment will result in a reduction of frontal flow and metabolism.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29MH048196-02
Application #
3475702
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1992-05-01
Project End
1993-11-30
Budget Start
1993-05-01
Budget End
1993-11-30
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130