Deficit symptoms can be successfully used to define reliable and valid subtypes of schizophrenia. These subtypes, deficit and non-deficit schizophrenia, differ on various clinical and functional measures. However, it is not known if there is a specific neuroanatomical substrate which underlies the production of these symptoms. The proposed project is designed to examine the involvement of specific cortical and subcortical structures hypothesized to be involved in the production of deficit symptoms. Seventy schizophrenic patients, subtyped into 35 deficit and 35 non-deficit patients, will undergo magnetic resonance imaging (MRI) and neuropsychological and neurological evaluations. The volume of the amygdala/hippocampus complex, caudate, and prefrontal and temporal cortices, as well as specific parietal and temporal gyri will be determined from three-dimensional """"""""spoiled grass"""""""" MRI images. Frontal, temporal, and parietal lobe function will be examined using selected neurological and neuropsychological tests. The volumetric, neurological, and neuropsychological measures will be used to test the hypothesis that a specific neural circuit, which includes the caudate and frontal and parietal cortices, is involved in the-production of deficit symptoms. In addition, the neurological and neuropsychological measures will be utilized to evaluate the functional significance of structural differences in these areas. The results from the patient group will be compared to similar measures obtained from thirty-five age, gender, and race matched normal controls. The use of the normal control group will provide a framework for interpreting the differences between deficit and non-deficit patients, as well as providing an opportunity to replicate and extend previous findings of structural differences between schizophrenic patients and normal controls.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29MH048225-05
Application #
2415959
Study Section
Biological Psychopathology Review Committee (BPP)
Project Start
1993-05-01
Project End
1998-04-30
Budget Start
1997-07-01
Budget End
1998-04-30
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Psychiatry
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Fischer, Bernard A; Keller, William R; Arango, Celso et al. (2012) Cortical structural abnormalities in deficit versus nondeficit schizophrenia. Schizophr Res 136:51-4
Arango, Celso; McMahon, Robert P; Lefkowitz, David M et al. (2008) Patterns of cranial, brain and sulcal CSF volumes in male and female deficit and nondeficit patients with schizophrenia. Psychiatry Res 162:91-100
Cohen, Alex S; Saperstein, Alice M; Gold, James M et al. (2007) Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to date. Schizophr Bull 33:1201-12
Giuliani, Nicole R; Calhoun, Vince D; Pearlson, Godfrey D et al. (2005) Voxel-based morphometry versus region of interest: a comparison of two methods for analyzing gray matter differences in schizophrenia. Schizophr Res 74:135-47
Buchanan, Robert W; Francis, Alan; Arango, Celso et al. (2004) Morphometric assessment of the heteromodal association cortex in schizophrenia. Am J Psychiatry 161:322-31
Tek, Cenk; Gold, James; Blaxton, Teresa et al. (2002) Visual perceptual and working memory impairments in schizophrenia. Arch Gen Psychiatry 59:146-53
Arango, C; Kirkpatrick, B; Buchanan, R W (2000) Neurological signs and the heterogeneity of schizophrenia. Am J Psychiatry 157:560-5
Bryant, N L; Buchanan, R W; Vladar, K et al. (1999) Gender differences in temporal lobe structures of patients with schizophrenia: a volumetric MRI study. Am J Psychiatry 156:603-9
Amador, X F; Kirkpatrick, B; Buchanan, R W et al. (1999) Stability of the diagnosis of deficit syndrome in schizophrenia. Am J Psychiatry 156:637-9
Arango, C; Bartko, J J; Gold, J M et al. (1999) Prediction of neuropsychological performance by neurological signs in schizophrenia. Am J Psychiatry 156:1349-57

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