Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29MH051699-03
Application #
2251036
Study Section
Molecular, Cellular, and Developmental Neurobiology Review Committee (MCDN)
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pharmacology
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Chrencik, Jill E; Roth, Christopher B; Terakado, Masahiko et al. (2015) Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell 161:1633-43
Sheng, Xiaoyan; Yung, Yun C; Chen, Allison et al. (2015) Lysophosphatidic acid signalling in development. Development 142:1390-5
Kihara, Yasuyuki; Mizuno, Hirotaka; Chun, Jerold (2015) Lysophospholipid receptors in drug discovery. Exp Cell Res 333:171-7
García-Díaz, Beatriz; Riquelme, Raquel; Varela-Nieto, Isabel et al. (2015) Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex. Brain Struct Funct 220:3701-20
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Groves, Aran; Kihara, Yasuyuki; Chun, Jerold (2013) Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci 328:9-18
Anliker, Brigitte; Choi, Ji Woong; Lin, Mu-En et al. (2013) Lysophosphatidic acid (LPA) and its receptor, LPA1 , influence embryonic schwann cell migration, myelination, and cell-to-axon segregation. Glia 61:2009-22
Lee, Sei-Jung; Leoni, Giovanna; Neumann, Philipp-Alexander et al. (2013) Distinct phospholipase C-? isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure. Mol Cell Biol 33:2016-28
Lin, Mu-En; Rivera, Richard R; Chun, Jerold (2012) Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain. J Biol Chem 287:17608-17

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