Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29NS024821-04
Application #
3476885
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1987-07-01
Project End
1991-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Appleton, Kathryn M; Bigham, Kevin J; Lindsey, Christopher C et al. (2014) Development of inhibitors of heterotrimeric G?i subunits. Bioorg Med Chem 22:3423-34
Oner, Sukru Sadik; Blumer, Joe B; Lanier, Stephen M (2013) Group II activators of G-protein signaling: monitoring the interaction of Gýý with the G-protein regulatory motif in the intact cell. Methods Enzymol 522:153-67
Kwon, Michelle; Pavlov, Tengis S; Nozu, Kandai et al. (2012) G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease. Proc Natl Acad Sci U S A 109:21462-7
Blumer, J B; Oner, S S; Lanier, S M (2012) Group II activators of G-protein signalling and proteins containing a G-protein regulatory motif. Acta Physiol (Oxf) 204:202-18
Simon, Violaine; Oner, Sukru S; Cohen-Tannoudji, Joelle et al. (2012) Influence of the accessory protein SET on M3 muscarinic receptor phosphorylation and G protein coupling. Mol Pharmacol 82:17-26
Chan, PuiYee; Gabay, Meital; Wright, Forrest A et al. (2011) Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf). J Biol Chem 286:2625-35
Regner, Kevin R; Nozu, Kandai; Lanier, Stephen M et al. (2011) Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents. FASEB J 25:1844-55
Sato, Motohiko; Hiraoka, Masahiro; Suzuki, Hiroko et al. (2011) Identification of transcription factor E3 (TFE3) as a receptor-independent activator of G?16: gene regulation by nuclear G? subunit and its activator. J Biol Chem 286:17766-76
Oner, Sukru Sadik; An, Ningfei; Vural, Ali et al. (2010) Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor. J Biol Chem 285:33949-58
Vural, Ali; Oner, Sadik; An, Ningfei et al. (2010) Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable. Mol Cell Biol 30:1528-40

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