Abstract

Biochemical analyses of Drosophila single-gene mutants, isolated for their effects on associative learning and memory, have implicated the monoamine-stimulated adenylate cyclase pathway. Behavioral analyses of other mutations isolated for their effects on specific biochemical or physiological systems will broaden our understanding of the biological mechanisms underlying associative learning and memory. Of particular interest are mutations affecting biogenic amine metabolism or neuronal ion channels, since they provide empirical tests of a current model of associative learning. Long-term memory formation will be studied in memory consolidation experiments and by assessing the stability of memory through metamorphosis in normal and mutant flies. A study of memory through metamorphosis in mutants with degenerated brain structures may identify specific anatomical sites involved with long-term memory storage or retrievel. Anatomical sites involved with associative learning also will be identified by generating flies mosaic for normal and mutant tissue. Behavioral analyses of learning or memory in these mosaics may reveal the existence of """"""""learning foci"""""""" in the brain.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29NS025621-02
Application #
3477203
Study Section
Neurology C Study Section (NEUC)
Project Start
1988-02-01
Project End
1993-01-31
Budget Start
1989-02-01
Budget End
1990-01-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Brandeis University
Department
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454

  Publications

Tully, T; Cambiazo, V; Kruse, L (1994) Memory through metamorphosis in normal and mutant Drosophila. J Neurosci 14:68-74
Yin, J C; Wallach, J S; Del Vecchio, M et al. (1994) Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79:49-58
Tully, T; Preat, T; Boynton, S C et al. (1994) Genetic dissection of consolidated memory in Drosophila. Cell 79:35-47
Luo, L; Tully, T; White, K (1992) Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron 9:595-605
Gailey, D A; Villella, A; Tully, T (1991) Reassessment of the effect of biological rhythm mutations on learning in Drosophila melanogaster. J Comp Physiol A 169:685-97
Tully, T; Boynton, S; Brandes, C et al. (1990) Genetic dissection of memory formation in Drosophila melanogaster. Cold Spring Harb Symp Quant Biol 55:203-11