The long range objective of this project is to apply the techniques of biochemistry and molecular biology to investigate gene expression and regulation in the nervous system. The nervous system is composed of a complex network of interconnected neurons. The diversity of this system is dependent upon the pattern of gene expression elicited in individual neurons. The underlying cause behind which genes are expressed in a particular cell type are not understood.
The specific aim of this project is to determine the mechanisms responsible for expression and regulation of the neuropeptide Y gene (NPY). NFY is the most abundant and widely expressed neuropeptide in the mammalian nervous system. Insight into the molecular mechanisms responsible for its gene expression will provide essential information concerning neuronal gene expression. The specific regions of the NPY promoter which are responsible for expression and tissuespecific expression will be studied. The DNA binding proteins which participate in manifesting NPY gene expression will be characterized. In addition, the response of the NPY gene to NGF will be investigated.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29NS028496-02
Application #
3478035
Study Section
Neurology C Study Section (NEUC)
Project Start
1990-04-01
Project End
1995-03-31
Budget Start
1991-04-01
Budget End
1992-03-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Wright State University
Department
Type
Schools of Medicine
DUNS #
City
Dayton
State
OH
Country
United States
Zip Code
45435