Abstract

A robust system for accurate, high-resolution magnetic resonance (MR) angiography is proposed. Initial emphasis will be placed on imaging the cerebral vascular system, especially the cervical carotid bifurcation with eventual generalization of the techniques to vessel imaging elsewhere in the body. The methodological focus will be on a blood tagging technique called selective inversion recovery (SIR) which can provide angiograms with sub-millimeter spatial resolution in scan times of less than 5 min. The research plan consists of engineering studies in several areas - flow artifacts, static material suppression, scan time, multiple views - which will improve and extend the SIR method and MR angiography in general. The method will be evaluated clinically on patients with cerebrovascular disorders, using comparative studies with other MR angiographic methods, x-ray contrast angiography and ultrasound.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29NS029434-03
Application #
3478273
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1991-05-01
Project End
1996-04-30
Budget Start
1993-05-01
Budget End
1994-04-30
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Engineering
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Vasanawala, S S; Pauly, J M; Nishimura, D G (2000) Linear combination steady-state free precession MRI. Magn Reson Med 43:82-90
Luk-Pat, G T; Gold, G E; Olcott, E W et al. (1999) High-resolution three-dimensional in vivo imaging of atherosclerotic plaque. Magn Reson Med 42:762-71
Nielsen, H T; Gold, G E; Olcott, E W et al. (1999) Ultra-short echo-time 2D time-of-flight MR angiography using a half-pulse excitation. Magn Reson Med 41:591-9
Vasanawala, S S; Sachs, T S; Brittain, J H et al. (1999) Prospective MR signal-based cardiac triggering. Magn Reson Med 42:82-6
Luk Pat, G T; Pauly, J M; Hu, B S et al. (1998) One-shot spatially resolved velocity imaging. Magn Reson Med 40:603-13
Mani, S; Pauly, J; Conolly, S et al. (1997) Background suppression with multiple inversion recovery nulling: applications to projective angiography. Magn Reson Med 37:898-905
Brittain, J H; Olcott, E W; Szuba, A et al. (1997) Three-dimensional flow-independent peripheral angiography. Magn Reson Med 38:343-54
Luk Pat, G T; Meyer, C H; Pauly, J M et al. (1997) Reducing flow artifacts in echo-planar imaging. Magn Reson Med 37:436-47
Nielsen, H T; Olcott, E W; Nishimura, D G (1997) Improved 2D time-of-flight angiography using a radial-line k-space acquisition. Magn Reson Med 37:285-91
Irarrazabal, P; Meyer, C H; Nishimura, D G et al. (1996) Inhomogeneity correction using an estimated linear field map. Magn Reson Med 35:278-82

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