Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29NS030137-05
Application #
2268190
Study Section
Neurology C Study Section (NEUC)
Project Start
1991-12-15
Project End
1996-11-30
Budget Start
1995-12-15
Budget End
1996-11-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Physiology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Harris, D A; Gorodinsky, A; Lehmann, S et al. (1996) Cell biology of the prion protein. Curr Top Microbiol Immunol 207:77-93
Gorodinsky, A; Harris, D A (1995) Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin. J Cell Biol 129:619-27
Shyng, S L; Lehmann, S; Moulder, K L et al. (1995) Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells. J Biol Chem 270:30221-9
Shyng, S L; Moulder, K L; Lesko, A et al. (1995) The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits. J Biol Chem 270:14793-800
Harris, D A; Huber, M T; van Dijken, P et al. (1993) Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites. Biochemistry 32:1009-16
Harris, D A; Lele, P; Snider, W D (1993) Localization of the mRNA for a chicken prion protein by in situ hybridization. Proc Natl Acad Sci U S A 90:4309-13
Shyng, S L; Huber, M T; Harris, D A (1993) A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells. J Biol Chem 268:15922-8