Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29NS030843-02
Application #
3478569
Study Section
Neurology C Study Section (NEUC)
Project Start
1992-07-01
Project End
1997-06-30
Budget Start
1993-02-01
Budget End
1993-06-30
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Gaublomme, Jellert T; Yosef, Nir; Lee, Youjin et al. (2015) Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity. Cell 163:1400-12
Wang, Chao; Yosef, Nir; Gaublomme, Jellert et al. (2015) CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity. Cell 163:1413-27
Wang, Chao; Collins, Mary; Kuchroo, Vijay K (2015) Effector T cell differentiation: are master regulators of effector T cells still the masters? Curr Opin Immunol 37:6-10
Zhu, Chen; Sakuishi, Kaori; Xiao, Sheng et al. (2015) An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun 6:6072
Wu, Chuan; Yosef, Nir; Thalhamer, Theresa et al. (2013) Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 496:513-7
Wu, Chuan; Pot, Caroline; Apetoh, Lionel et al. (2013) Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A 110:7802-7
Yosef, Nir; Shalek, Alex K; Gaublomme, Jellert T et al. (2013) Dynamic regulatory network controlling TH17 cell differentiation. Nature 496:461-8
Liu, Sue M; Sutherland, Andrew P R; Zhang, Zheng et al. (2012) Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. J Immunol 188:155-62
Vignali, Dario A A; Kuchroo, Vijay K (2012) IL-12 family cytokines: immunological playmakers. Nat Immunol 13:722-8
Lee, Youjin; Awasthi, Amit; Yosef, Nir et al. (2012) Induction and molecular signature of pathogenic TH17 cells. Nat Immunol 13:991-9

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