Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29NS032806-02
Application #
2271248
Study Section
Neurology A Study Section (NEUA)
Project Start
1995-07-01
Project End
2000-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Dijkhuizen, Rick M; Asahi, Minoru; Wu, Ona et al. (2002) Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke 33:2100-4
Singhal, Aneesh B; Dijkhuizen, Rick M; Rosen, Bruce R et al. (2002) Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology 58:945-52
Singhal, Aneesh B; Wang, Xiaoying; Sumii, Toshihisa et al. (2002) Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 22:861-8
Wang, X; Shimizu-Sasamata, M; Moskowitz, M A et al. (2001) Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice. Neurosci Lett 313:121-4
Tejima, E; Katayama, Y; Suzuki, Y et al. (2001) Hemorrhagic transformation after fibrinolysis with tissue plasminogen activator: evaluation of role of hypertension with rat thromboembolic stroke model. Stroke 32:1336-40
Sumii, T; Singhal, A B; Asahi, M et al. (2001) Protective effects of pamiteplase, a modified t-PA, in a rat model of embolic stroke. Neuroreport 12:615-8
Dijkhuizen, R M; Asahi, M; Wu, O et al. (2001) Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab 21:964-71
Asahi, M; Asahi, K; Wang, X et al. (2000) Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 20:452-7
Matsushita, K; Meng, W; Wang, X et al. (2000) Evidence for apoptosis after intercerebral hemorrhage in rat striatum. J Cereb Blood Flow Metab 20:396-404
Kano, T; Katayama, Y; Tejima, E et al. (2000) Hemorrhagic transformation after fibrinolytic therapy with tissue plasminogen activator in a rat thromboembolic model of stroke. Brain Res 854:245-8

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