Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29NS033142-02
Application #
2271739
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1995-04-01
Project End
2000-02-29
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Neurology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Yen, L; Gonzalez-Zulueta, M; Feldman, A et al. (2001) Reduction of functional N-methyl-D-aspartate receptors in neurons by RNase P-mediated cleavage of the NR1 mRNA. J Neurochem 76:1386-94
Facchinetti, F; Sasaki, M; Cutting, F B et al. (1999) Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis. Neuroscience 90:1483-92
Yun, H Y; Dawson, V L; Dawson, T M (1999) Glutamate-stimulated calcium activation of Ras/Erk pathway mediated by nitric oxide. Diabetes Res Clin Pract 45:113-5
Dawson, T M; Sasaki, M; Gonzalez-Zulueta, M et al. (1998) Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways. Prog Brain Res 118:3-11
Crosbie, R H; Straub, V; Yun, H Y et al. (1998) mdx muscle pathology is independent of nNOS perturbation. Hum Mol Genet 7:823-9
Yun, H Y; Gonzalez-Zulueta, M; Dawson, V L et al. (1998) Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21ras. Proc Natl Acad Sci U S A 95:5773-8
Dawson, V L; Dawson, T M (1998) Nitric oxide in neurodegeneration. Prog Brain Res 118:215-29
Jumrussirikul, P; Dinerman, J; Dawson, T M et al. (1998) Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice. J Clin Invest 102:1279-85
Gonzalez-Zulueta, M; Ensz, L M; Mukhina, G et al. (1998) Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity. J Neurosci 18:2040-55
Szabo, C; Dawson, V L (1998) Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion. Trends Pharmacol Sci 19:287-98

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