Functional MRI (FMRI) with blood-oxygenation level dependent (BOLD) image-contrast provides unparalleled spatial resolution for mapping of human cerebral function. The BOLD image-contrast is determined by regional values of cerebral blood flow (CBF) and cerebral metabolic rate of oxygen consumption (CMRO). However, the relationship between BOLD image-contrast with CBF and CMR02 is not known quantitatively. Due to this uncertainty, to date, the BOLD method does not provide a direct measure of functional cortical activity. The objective of this proposal is to calibrate the BOLD signal with respect to blood oxygenation such that a high spatial resolution CMRO2 map can be obtained by combination of BOLD and CBF maps. By quantitative coregistration of CMR02 and CBF maps with autoradiographic maps of deoxyglucose consumption, during functional activation, the BOLD FMRI method will be converted into a technique that maps cortical activity. Applications of a quantitative BOLD FMRI method would include human brain mapping of sensory and cognitive functions, assessment of altered cortical activity in the diseased or injured brain, and long-term investigations of brain development and functional plasticity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29NS037203-01A1
Application #
2705240
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Jacobs, Tom P
Project Start
1998-07-01
Project End
2003-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Yale University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Herman, Peter; Trubel, Hubert K F; Hyder, Fahmeed (2006) A multiparametric assessment of oxygen efflux from the brain. J Cereb Blood Flow Metab 26:79-91
Kida, Ikuhiro; Hyder, Fahmeed (2006) Physiology of functional magnetic resonance imaging: energetics and function. Methods Mol Med 124:175-95
Xu, Fuqiang; Schaefer, Michele; Kida, Ikuhiro et al. (2005) Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones. J Comp Neurol 489:491-500
Hyder, Fahmeed (2004) Neuroimaging with calibrated FMRI. Stroke 35:2635-41
Liu, Nian; Xu, Fuqiang; Marenco, Luis et al. (2004) Informatics approaches to functional MRI odor mapping of the rodent olfactory bulb: OdorMapBuilder and OdorMapDB. Neuroinformatics 2:3-18
Kida, Ikuhiro; Maciejewski, Paul K; Hyder, Fahmeed (2004) Dynamic imaging of perfusion and oxygenation by functional magnetic resonance imaging. J Cereb Blood Flow Metab 24:1369-81
Nersesyan, Hrachya; Hyder, Fahmeed; Rothman, Douglas L et al. (2004) Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats. J Cereb Blood Flow Metab 24:589-99
Nersesyan, Hrachya; Herman, Peter; Erdogan, Ersan et al. (2004) Relative changes in cerebral blood flow and neuronal activity in local microdomains during generalized seizures. J Cereb Blood Flow Metab 24:1057-68
Trubel, Hubert; Herman, Peter; Kampmann, Christoph et al. (2004) A novel approach for selective brain cooling: implications for hypercapnia and seizure activity. Intensive Care Med 30:1829-33
Hyder, Fahmeed; Kida, Ikuhiro; Behar, Kevin L et al. (2003) Dominant events that modulate mass transfer coefficient of oxygen in cerebral cortex. Adv Exp Med Biol 530:401-11

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