Recently, the optical imaging field has been rapidly expanding in scope through the use of new exogenous molecular probes. We have already developed a multi-frequency & multi- spectral optical tomography animal imaging system and integrated to an MRI system. In this application, we will expand our hybrid system to measure dynamic information from exogenous probes. This system would measure the enhancement kinetics of the bi-functional MR/NIR or mono-functional NIR contrast agents in addition to the endogenous contrast due to hemoglobin contents and scattering properties. There are two main phases of the proposal. The first and the foremost phase is the technology development, which can be classified into two sub aims: a) the development of a novel multi-modality dynamic imaging system and b) the development of polymer based bi-functional and mono-functional NIR agents. We believe that such a hybrid system will facilitate the development of new contrast agents for biomedical imaging and that the development of polymer based molecular agents will provide a potential new molecular platform for these new contrast agents. In the second phase of the proposal, we will try to utilize this novel hybrid system together with a small molecular MR and a medium size (~30-40 kDa) novel polymer based optical agent. We will compare the role of all kinetic parameters and intrinsic properties obtained by MR/Optical imaging system, individually or combined, in cancer diagnosis after completing all analysis steps. Thus, we will be able to test our hypothesis that """"""""the parameters obtained by macromolecular optical agent together with total hemoglobin, oxygen saturation and tissue scattering parameters can achieve a higher specificity in differentiating between ENU induced malignant and benign tumors compared to MRI parameters measured by low molecular weight extracellular MRI agents"""""""". We believe our collaboration with GE Global Research Center for the development of the novel MR/NIR contrast agents will serve to close the gap between the academia and the industries further for biomedical imaging applications. If successful, the outcome of our effort will offer a sophisticated tool that could provide high sensitivity and high specificity in the detection and characterization of tumors. With appropriate modifications in design, the proposed MR/Optical technology has a great translational potential for future human clinical trials. This application is aimed at developing a hybrid MR/DOT system along with novel polymer based contrast agents. If successful, the outcome of our effort will offer a sophisticated tool that could provide high sensitivity and high specificity in the detection and characterization of tumors. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants Phase II (R33)
Project #
4R33CA120175-02
Application #
7665201
Study Section
Special Emphasis Panel (ZRG1-SBIB-J (51))
Program Officer
Baker, Houston
Project Start
2007-08-01
Project End
2011-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
2
Fiscal Year
2008
Total Cost
$481,533
Indirect Cost
Name
University of California Irvine
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Luk, Alex T; Ha, Seunghoon; Nouizi, Farouk et al. (2014) A True Multi-modality Approach for High Resolution Optical Imaging: Photo-Magnetic Imaging. Proc SPIE Int Soc Opt Eng 8937:
Lin, Yuting; Gao, Hao; Thayer, David et al. (2013) Photo-magnetic imaging: resolving optical contrast at MRI resolution. Phys Med Biol 58:3551-62
Thayer, David A; Lin, Yuting; Luk, Alex et al. (2012) Laser-induced photo-thermal magnetic imaging. Appl Phys Lett 101:83703
Lin, Yuting; Kwong, Tiffany C; Bolisay, Linden et al. (2012) Temperature-modulated fluorescence tomography based on both concentration and lifetime contrast. J Biomed Opt 17:056007
Lin, Yuting; Bolisay, Linden; Ghijsen, Michael et al. (2012) Temperature-modulated fluorescence tomography in a turbid media. Appl Phys Lett 100:73702-737024
Lin, Yuting; Ghijsen, Michael; Nalcioglu, Orhan et al. (2012) In vivo validation of quantitative frequency domain fluorescence tomography. J Biomed Opt 17:126021
Lin, Y; Ghijsen, M T; Gao, H et al. (2011) A photo-multiplier tube-based hybrid MRI and frequency domain fluorescence tomography system for small animal imaging. Phys Med Biol 56:4731-47
Lin, Yuting; Barber, William C; Iwanczyk, Jan S et al. (2010) Quantitative fluorescence tomography using a trimodality system: in vivo validation. J Biomed Opt 15:040503
Gao, Hao; Lin, Yuting; Gulsen, Gultekin et al. (2010) Fully linear reconstruction method for fluorescence yield and lifetime through inverse complex-source formulation: simulation studies. Opt Lett 35:1899-901
Barber, W C; Lin, Y; Nalcioglu, O et al. (2010) Combined fluorescence and X-Ray tomography for quantitative in vivo detection of fluorophore. Technol Cancer Res Treat 9:45-52

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