The proposed research will address the need for higher resolution in vivo imaging by bringing together recent innovations in radiation detectors, multiple-pinhole imaging apertures, and reconstruction algorithms in the development of an ultrahigh-resolution tomographic imaging system. The device will utilize silicon double-sided strip detectors (DSSDs) whose intrinsic position resolution will be at least an order of magnitude better than conventional scintillation cameras used in nuclear medicine. The silicon detectors that are to be used are well-suited to the detection of the low- energy (27-35 keV) photons from the decay of 1251 and 1231. The ability to iodinate a wide range of molecules makes such a system applicable to many uses, particularly in the field of small-animal imaging.
| Peterson, Todd E; Shokouhi, Sepideh (2012) Advances in preclinical SPECT instrumentation. J Nucl Med 53:841-4 |
| Shokouhi, S; Wilson, D W; Metzler, S D et al. (2010) Evaluation of image reconstruction for mouse brain imaging with synthetic collimation from highly multiplexed SiliSPECT projections. Phys Med Biol 55:5151-68 |
| Shokouhi, Sepideh; McDonald, Benjamin S; Durko, Heather L et al. (2009) Thick Silicon Double-Sided Strip Detectors for Low-Energy Small-Animal SPECT. IEEE Trans Nucl Sci 56:557-564 |
| Shokouhi, S; Metzler, S D; Wilson, D W et al. (2009) Multi-pinhole collimator design for small-object imaging with SiliSPECT: a high-resolution SPECT. Phys Med Biol 54:207-25 |
| Peterson, Todd E; Shokouhi, Sepideh; Furenlid, Lars R et al. (2009) Multi-pinhole SPECT Imaging with Silicon Strip Detectors. IEEE Trans Nucl Sci 56:646-652 |
