Abstract

3 oaae.s) 1Z_ Introduction to SuoDlemental Aoolication (Not to exceed one oaoe) A. SoecificAims ^R-21^ B. Backaround and Sianificance 2J C. Preliminary Studies 2pound D. Research Desian and Methods (R-21) 29 Milestones (R-2V __M__ A. Soecific Aims (R-33) 35 D. Research Desian and Methods (R-33^ 3pound H. Human Subjects 44 I. Vertebrate Animals 44 J. Literature Cited 45 K. Consortium/ContractualArranaements 5J_ Checklist 54 Appendix (Five collated sets. Nopage numbering necessary for Appendix ) Check if Appendix is Appendices NOT PERMITTED forPhase I SBIR/STTR unless specifically solicited. Included Number of publications and manuscripts accepted for publication (not to exceed 10) Other items (list): PHS 398 (Rev. 05/01) Page 3 Form Page 3

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory/Developmental Grants Phase II (R33)
Project #
5R33RR020046-05
Application #
7628332
Study Section
Special Emphasis Panel (ZRR1-BT-6 (01))
Program Officer
Friedman, Fred K
Project Start
2005-09-28
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2011-06-30
Support Year
5
Fiscal Year
2009
Total Cost
$303,437
Indirect Cost

  Institution

Name
Washington State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164

  Publications

Li, Hongli; Bendiak, Brad; Siems, William F et al. (2015) Determining the isomeric heterogeneity of neutral oligosaccharide-alditols of bovine submaxillary mucin using negative ion traveling wave ion mobility mass spectrometry. Anal Chem 87:2228-35
Williams, Michael D; Zhang, Xing; Belton, Amy S et al. (2015) HMGA1 drives metabolic reprogramming of intestinal epithelium during hyperproliferation, polyposis, and colorectal carcinogenesis. J Proteome Res 14:1420-31
Williams, Michael D; Zhang, Xing; Park, Jeong-Jin et al. (2015) Characterizing metabolic changes in human colorectal cancer. Anal Bioanal Chem 407:4581-95
Li, Hongli; Bendiak, Brad; Siems, William F et al. (2013) Ion Mobility-Mass Correlation Trend Line Separation of Glycoprotein Digests without Deglycosylation. Int J Ion Mobil Spectrom 16:105-115
Li, Hongli; Bendiak, Brad; Siems, William F et al. (2013) Ion mobility mass spectrometry analysis of isomeric disaccharide precursor, product and cluster ions. Rapid Commun Mass Spectrom 27:2699-709
Li, Hongli; Bendiak, Brad; Siems, William F et al. (2013) Carbohydrate structure characterization by tandem ion mobility mass spectrometry (IMMS)2. Anal Chem 85:2760-9
Zakharova, Natalia L; Crawford, Christina L; Hauck, Brian C et al. (2012) An assessment of computational methods for obtaining structural information of moderately flexible biomolecules from ion mobility spectrometry. J Am Soc Mass Spectrom 23:792-805
Li, Hongli; Giles, Kevin; Bendiak, Brad et al. (2012) Resolving structural isomers of monosaccharide methyl glycosides using drift tube and traveling wave ion mobility mass spectrometry. Anal Chem 84:3231-9
Fernández-Maestre, Roberto; Harden, Charles Steve; Ewing, Robert Gordon et al. (2010) Chemical standards in ion mobility spectrometry. Analyst 135:1433-42
Dwivedi, Prabha; Schultz, Albert J; Hill, Herbert H (2010) Metabolic Profiling of Human Blood by High Resolution Ion Mobility Mass Spectrometry (IM-MS). Int J Mass Spectrom 298:78-90

Showing the most recent 10 out of 15 publications