Bipolar disorder (BD) in youth is associated with significant impairments in functioning, treatment-resistance, and high public health costs. Recent research on prodromal forms of BD have identified symptomatic risk factors which increase the chances that genetically predisposed children will develop BD I or II disorder. The long-term goal of our research is to reduce the likelihood of or delay the full expression of BD among at-risk youth.
The aim of this first phase (R34) is to develop and test a manual-based early psychoeducational intervention - family-focused treatment (FFT) - to determine if a large-scale early intervention trial with longer follow-up is warranted. FFT, consisting of psychoeducation, communication enhancement training, and problem-solving skills training, has been found to be effective in combination with pharmacotherapy in preventing recurrences and stabilizing the symptoms of adults and adolescents with BD. The present study consists of two phases and will be conducted at two sites: the University of Colorado (primary applicant site; D. Miklowitz, PI) and Stanford University (secondary site; K. Chang, Co-PI). In Phase I, we will identify 12 children aged 9-17 with putative prodromal BD who meet study criteria for high risk (i.e., have a first-degree relative with bipolar I or II disorder and meet criteria for BD not otherwise specified, cyclothymia, or major depressive disorder with hypomanic symptoms). In phase I, we will develop a manual for a 4-month, 12-session version of FFT for children at risk for BD, test therapist fidelity scales, and revise the manual in an iterative fashion in response to clinician and consumer feedback. We will examine consumer acceptance of the intervention and pre/post changes in the symptoms and functioning of the at-risk children (depression and mania scores, psychiatric status on the Adolescent Longitudinal Interval Follow-up) over a 1-year period. In phase II, we will randomly assign 40 high-risk children to either the newly manualized FFT or a treatment-as-usual (TAU) comparison. All children who require pharmacotherapy will receive it from study psychiatrists following best- practice guidelines. Participants in phase II will be examined over one year to test the hypothesis that FFT is more effective than TAU in reducing the severity of manic and depressive symptoms, increasing the amount of time spent well, delaying the onset of first manic, mixed or hypomanic episodes, improving functioning, decreasing distress among parents, and increasing the child's access to appropriate mental health services. The data analytic plan emphasizes mixed effects regression and survival analytic models. With 40 participants, phase II is well-powered to detect large and medium effect sizes assuming expected rates of attrition. The pilot trial will produce a finalized treatment manual that should be exportable to other treatment sites. It will yield estimates of population variability in targeted outcomes as a function of treatments, which should inform the development of a larger-scale early intervention trial. Principal Investigator/Program Director: Miklowitz, David J. Project Narrative We propose a treatment development project focused on manualizing, standardizing, and conducting an initial test of effectiveness of a 12-session version of family-focused treatment (FFT) for youth (ages 9-17) at high-risk for bipolar disorder, an illness with considerable morbidity, risk for suicidality, and disability. We hope to show that (a) early, brief intervention with FFT will decrease mood and behavioral symptoms, improve social and academic functioning, improve family interactions, and provide the at-risk child with the skills to cope effectively with interpersonal stressors; (b) help parents to better regulate their own emotional states; (c) make parents """"""""educated consumers"""""""" who effectively advocate for appropriate treatments for their children. Thus, FFT could prove to be a cost-effective (compared to individual treatment with child and parent) and easily disseminable intervention with great potential to prevent or ameliorate the natural progression of bipolar disorder in at-risk youth. ? ? ?
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| Schneck, Christopher D; Chang, Kiki D; Singh, Manpreet K et al. (2017) A Pharmacologic Algorithm for Youth Who Are at High Risk for Bipolar Disorder. J Child Adolesc Psychopharmacol 27:796-805 |
| Garrett, Amy S; Miklowitz, David J; Howe, Meghan E et al. (2015) Changes in brain activation following psychotherapy for youth with mood dysregulation at familial risk for bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 56:215-20 |
| Miklowitz, David J; Schneck, Christopher D; George, Elizabeth L et al. (2014) Pharmacotherapy and family-focused treatment for adolescents with bipolar I and II disorders: a 2-year randomized trial. Am J Psychiatry 171:658-67 |
| Miklowitz, David J; Schneck, Christopher D; Singh, Manpreet K et al. (2013) Early intervention for symptomatic youth at risk for bipolar disorder: a randomized trial of family-focused therapy. J Am Acad Child Adolesc Psychiatry 52:121-31 |
| Keenan-Miller, Danielle; Peris, Tara; Axelson, David et al. (2012) Family functioning, social impairment, and symptoms among adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 51:1085-94 |
| Miklowitz, David J (2012) Family treatment for bipolar disorder and substance abuse in late adolescence. J Clin Psychol 68:502-13 |
| Sullivan, Aimee E; Judd, Charles M; Axelson, David A et al. (2012) Family functioning and the course of adolescent bipolar disorder. Behav Ther 43:837-47 |
| Miklowitz, David J; Price, Jonathan; Holmes, Emily A et al. (2012) Facilitated Integrated Mood Management for adults with bipolar disorder. Bipolar Disord 14:185-97 |
| Miklowitz, David J (2011) Functional impairment, stress, and psychosocial intervention in bipolar disorder. Curr Psychiatry Rep 13:504-12 |
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