Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
7R35CA039807-12
Application #
2089957
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1985-09-11
Project End
1999-06-30
Budget Start
1996-01-25
Budget End
1996-06-30
Support Year
12
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Sharina, I G; Zhao, R; Wang, Y et al. (2001) Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier. Mol Pharmacol 59:1022-8
Zhao, R; Gao, F; Goldman, I D (2001) Molecular cloning of human thiamin pyrophosphokinase. Biochim Biophys Acta 1517:320-2
Zhao, R; Russell, R G; Wang, Y et al. (2001) Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs. J Biol Chem 276:10224-8
Rajgopal, A; Sierra, E E; Zhao, R et al. (2001) Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities. Am J Physiol Cell Physiol 281:C1579-86
Wang, Y; Zhao, R; Russell, R G et al. (2001) Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis. Biochim Biophys Acta 1513:49-54
Zhao, R; Gao, F; Wang, Y et al. (2001) Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells. J Biol Chem 276:1114-8
Zhao, R; Gao, F; Goldman, I D (2001) Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells. Biochem Pharmacol 61:857-65
Zhao, R; Gao, F; Liu, L et al. (2000) The reduced folate carrier in L1210 murine leukemia cells is a 58-kDa protein. Biochim Biophys Acta 1466:10-Jul
Zhao, R; Titus, S; Gao, F et al. (2000) Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase. J Biol Chem 275:26599-606
Zhao, R; Gao, F; Babani, S et al. (2000) Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier. Clin Cancer Res 6:3304-11

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