Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA039836-03
Application #
3479173
Study Section
(SRC)
Project Start
1985-07-01
Project End
1992-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
Fan, J; Kureshy, N; Vitols, K S et al. (1995) Novel substrate analogs delineate an endocytotic mechanism for uptake of folate via the high-affinity, glycosylphosphatidylinositol-linked transport protein in L1210 mouse leukemia cells. Oncol Res 7:511-6
Vitols, K S; Haag-Zeino, B; Baer, T et al. (1995) Methotrexate-alpha-phenylalanine: optimization of methotrexate prodrug for activation by carboxypeptidase A-monoclonal antibody conjugate. Cancer Res 55:478-81
Huennekens, F M (1994) The methotrexate story: a paradigm for development of cancer chemotherapeutic agents. Adv Enzyme Regul 34:397-419
Huennekens, F M (1994) Tumor targeting: activation of prodrugs by enzyme-monoclonal antibody conjugates. Trends Biotechnol 12:234-9
Fan, J; Vitols, K S; Huennekens, F M (1992) Multiple folate transport systems in L1210 cells. Adv Enzyme Regul 32:3-15
Huennekens, F M; Vitols, K S; Pope, L E et al. (1992) Membrane transport of folate compounds. J Nutr Sci Vitaminol (Tokyo) Spec No:52-7
Haenseler, E; Esswein, A; Vitols, K S et al. (1992) Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate. Biochemistry 31:891-7
Fan, J G; Pope, L E; Vitols, K S et al. (1991) Affinity labeling of folate transport proteins with the N-hydroxysuccinimide ester of the gamma-isomer of fluorescein-methotrexate. Biochemistry 30:4573-80
Fan, J; Vitols, K S; Huennekens, F M (1991) Biotin derivatives of methotrexate and folate. Synthesis and utilization for affinity purification of two membrane-associated folate transporters from L1210 cells. J Biol Chem 266:14862-5
Esswein, A; Hanseler, E; Montejano, Y et al. (1991) Construction and chemotherapeutic potential of carboxypeptidase-A/monoclonal antibody conjugate. Adv Enzyme Regul 31:3-12

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