I propose to engage in several activities, all designed to illuminate the etiology of neoplastic disease. I will supervise case-control studies in test of specific etiologic hypotheses suited to that method. The first will be of pancreas cancer in relation to diet and atopic disease, and of aggressive (metastatic or invasive through the myometrium) endometrial cancer in relation to exogenous estrogen use. I will continue to develop a registry of twins with cancer and perform co-twin studies of breast cancer, colon and other GI cancer, malignant melanoma, and other neoplasms. I will perform follow up on unaffected twins in relation to their stated exposures, and utilize population-based twin registries in California and Sweden for various adjunct studies. I will begin a cohort study in high risk individuals designed to elevate the determinants and implications of acquired benign pigmented lesions. I will continue to use cancer and registry information for descriptive studies, including estimation of the observed and expected rates of conjugal site-specific cancer, of the incidence among those residing near geographic foci of contamination with toxic wastes, and of disease-specific concordance in twins and the implications for interpretation of familiality and heritability. Finally, I will design a program to facilitate laboratory investigations making use of material from twins in the registry; such a program could provide a unique integration of high quality epidemiologic study design and """"""""state of the art"""""""" lab techniques.
| Ursin, Giske; Lillie, Elizabeth O; Lee, Eunjung et al. (2009) The relative importance of genetics and environment on mammographic density. Cancer Epidemiol Biomarkers Prev 18:102-12 |
| Islam, Talat; Gauderman, W James; Cozen, Wendy et al. (2007) Childhood sun exposure influences risk of multiple sclerosis in monozygotic twins. Neurology 69:381-8 |
| Islam, Talat; Gauderman, W James; Cozen, Wendy et al. (2006) Differential twin concordance for multiple sclerosis by latitude of birthplace. Ann Neurol 60:56-64 |
| Baker, Stuart G; Lichtenstein, Paul; Kaprio, Jaakko et al. (2005) Genetic susceptibility to prostate, breast, and colorectal cancer among Nordic twins. Biometrics 61:55-63 |
| Tomassini, Cecilia; Juel, Knud; Holm, Niels V et al. (2003) Risk of suicide in twins: 51 year follow up study. BMJ 327:373-4 |
| Hamilton, Ann S; Mack, Thomas M (2003) Puberty and genetic susceptibility to breast cancer in a case-control study in twins. N Engl J Med 348:2313-22 |
| Mack, T M; Hamilton, A S; Press, M F et al. (2002) Heritable breast cancer in twins. Br J Cancer 87:294-300 |
| Swerdlow, Anthony J; De Stavola, Bianca L; Floderus, Birgitta et al. (2002) Risk factors for breast cancer at young ages in twins: an international population-based study. J Natl Cancer Inst 94:1238-46 |
| Cockburn, M; Hamilton, A; Mack, T (2001) Recall bias in self-reported melanoma risk factors. Am J Epidemiol 153:1021-6 |
| Cockburn, M; Black, W; McKelvey, W et al. (2001) Determinants of melanoma in a case-control study of twins (United States). Cancer Causes Control 12:615-25 |
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