Abstract

Nitrosamines and polynuclear aromatic hydrocarbons (PAH) are prevalent environmental carcinogens and excellent model compounds for the induction of a variety of tumor types. The major goal of the proposed research is to determine the mechanisms by which nitrosamines and PAH interact with DNA to initiate the carcinogenic process. This knowledge will be used to develop practical strategies for cancer prevention.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA044377-03
Application #
3479602
Study Section
(SRC)
Project Start
1987-09-01
Project End
1994-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Institute for Cancer Prevention
Department
Type
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595

  Publications

Amin, Shantu; Lin, Jyh-Ming; Krzeminski, Jacek et al. (2003) Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats. Chem Res Toxicol 16:227-31
Upadhyaya, Pramod; Zimmerman, Cheryl L; Hecht, Stephen S (2002) Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey. Drug Metab Dispos 30:1115-22
Simpson, C D; Wu, M T; Christiani, D C et al. (2000) Determination of r-7,t-8,9,c-10-tetrahydroxy-7,8,9, 10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography/negative ion chemical ionization/mass spectrometry. Chem Res Toxicol 13:271-80
Trushin, N; Hecht, S S (1999) Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats. Chem Res Toxicol 12:164-71
Lackmann, G M; Salzberger, U; Tollner, U et al. (1999) Metabolites of a tobacco-specific carcinogen in urine from newborns. J Natl Cancer Inst 91:459-65
Lin, J M; Desai, D; Chung, L et al. (1999) Synthesis of anti-7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydro-11-methylbenzo[a]pyrene and its reaction with DNA. Chem Res Toxicol 12:341-6
Hecht, S S; Carmella, S G; Chen, M et al. (1999) Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation. Cancer Res 59:590-6
Hecht, S S (1999) Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst 91:1194-210
Hecht, S S (1999) DNA adduct formation from tobacco-specific N-nitrosamines. Mutat Res 424:127-42
Hecht, S S; Hatsukami, D K; Bonilla, L E et al. (1999) Quantitation of 4-oxo-4-(3-pyridyl)butanoic acid and enantiomers of 4-hydroxy-4-(3-pyridyl)butanoic acid in human urine: A substantial pathway of nicotine metabolism. Chem Res Toxicol 12:172-9

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