Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA018808-22
Application #
2086727
Study Section
Special Emphasis Panel (NSS)
Project Start
1975-09-01
Project End
1997-12-31
Budget Start
1996-06-01
Budget End
1997-12-31
Support Year
22
Fiscal Year
1996
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Genetics
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Jackson, P; Mastrangelo, I; Reed, M et al. (1998) Synergistic transcriptional activation of the MCK promoter by p53: tetramers link separated DNA response elements by DNA looping. Oncogene 16:283-92
Anderson, M E; Woelker, B; Reed, M et al. (1997) Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation. Mol Cell Biol 17:6255-64
Ray, S; Anderson, M E; Tegtmeyer, P (1996) Differential interaction of temperature-sensitive simian virus 40 T antigens with tumor suppressors pRb and p53. J Virol 70:7224-7
McVey, D; Woelker, B; Tegtmeyer, P (1996) Mechanisms of simian virus 40 T-antigen activation by phosphorylation of threonine 124. J Virol 70:3887-93
Reed, M; Woelker, B; Wang, P et al. (1995) The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proc Natl Acad Sci U S A 92:9455-9
Wang, Y; Schwedes, J F; Parks, D et al. (1995) Interaction of p53 with its consensus DNA-binding site. Mol Cell Biol 15:2157-65
Rainwater, R; Parks, D; Anderson, M E et al. (1995) Role of cysteine residues in regulation of p53 function. Mol Cell Biol 15:3892-903
Stenger, J E; Tegtmeyer, P; Mayr, G A et al. (1994) p53 oligomerization and DNA looping are linked with transcriptional activation. EMBO J 13:6011-20
Wang, P; Reed, M; Wang, Y et al. (1994) p53 domains: structure, oligomerization, and transformation. Mol Cell Biol 14:5182-91
Reed, M; Wang, Y; Mayr, G et al. (1993) p53 domains: suppression, transformation, and transactivation. Gene Expr 3:95-107

Showing the most recent 10 out of 39 publications