Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA047486-07
Application #
2007713
Study Section
Special Emphasis Panel (SRC (N2))
Project Start
1990-08-15
Project End
1997-07-31
Budget Start
1996-08-26
Budget End
1997-07-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Institute for Cancer Research
Department
Type
DUNS #
872612445
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
Lubkowski, J; Dauter, Z; Yang, F et al. (1999) Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant. Biochemistry 38:13512-22
Asante-Appiah, E; Merkel, G; Skalka, A M (1998) Purification of untagged retroviral integrases by immobilized metal ion affinity chromatography. Protein Expr Purif 12:105-10
Bouck, J; Fu, X D; Skalka, A M et al. (1998) Role of the constitutive splicing factors U2AF65 and SAP49 in suboptimal RNA splicing of novel retroviral mutants. J Biol Chem 273:15169-76
Lubkowski, J; Yang, F; Alexandratos, J et al. (1998) Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrase. J Biol Chem 273:32685-9
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Asante-Appiah, E; Skalka, A M (1997) A metal-induced conformational change and activation of HIV-1 integrase. J Biol Chem 272:16196-205
Asante-Appiah, E; Skalka, A M (1997) Molecular mechanisms in retrovirus DNA integration. Antiviral Res 36:139-56
Bujacz, G; Jaskolski, M; Alexandratos, J et al. (1996) The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations. Structure 4:89-96
Levy-Mintz, P; Duan, L; Zhang, H et al. (1996) Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase. J Virol 70:8821-32

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