Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
3R35CA053913-06S1
Application #
2095579
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1991-05-15
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Keck, M V; Manderville, R A; Hecht, S M (2001) Chemical and structural characterization of the interaction of bleomycin A2 with d(CGCGAATTCGCG)2. efficient, double-strand DNA cleavage accessible without structural reorganization. J Am Chem Soc 123:8690-700
Sznaidman, M L; Hecht, S M (2001) Studies on the total synthesis of tallysomycin. Synthesis of the threonylbithiazole moiety containing a structurally unique glycosylcarbinolamide. Org Lett 3:2811-4
Zhou, B N; Johnson, R K; Mattern, M R et al. (2000) Isolation and biochemical characterization of a new topoisomerase I inhibitor from Ocotea leucoxylon. J Nat Prod 63:217-21
Hecht, S M (2000) Bleomycin: new perspectives on the mechanism of action. J Nat Prod 63:158-68
Wang, X; Zhou, X; Hecht, S M (1999) Role of the 20-hydroxyl group in camptothecin binding by the topoisomerase I-DNA binary complex. Biochemistry 38:4374-81
Arslan, T; Abraham, A T; Hecht, S M (1998) DNA duplexes containing 3'-deoxynucleotides as substrates for DNA topoisomerase I cleavage and ligation. J Biol Chem 273:12383-90
Wang, X; Wang, L K; Kingsbury, W D et al. (1998) Differential effects of camptothecin derivatives on topoisomerase I-mediated DNA structure modification. Biochemistry 37:9399-408
Arslan, T; Abraham, A T; Hecht, S M (1998) Structurally altered substrates for DNA topoisomerase I. Effects of inclusion of a single 3'-deoxynucleotide within the scissile strand. Nucleosides Nucleotides 17:515-30
Wang, X; Henningfeld, K A; Hecht, S M (1998) DNA topoisomerase I-mediated formation of structurally modified DNA duplexes. Effects of metal ions and topoisomerase I inhibitors. Biochemistry 37:2691-700
Holmes, C E; Duff, R J; van der Marel, G A et al. (1997) On the chemistry of RNA degradation by Fe.bleomycin. Bioorg Med Chem 5:1235-48

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