Public Health Relevance

Oxylipins are fatty acid derivatives that play an important role in inflammation ? serving as pro-inflammatory, anti-inflammatory, and/or pro-resolving signals depending on the compound and the context. This proposal will investigate how oxylipin signaling occurs between cell types to better understand oxylipin mechanisms in normal physiology and diseases with deregulated inflammation (such as asthma, infection, benign hyperplasia, and cancer). We will develop a suite of microfluidic tools to broaden the scope of mechanistic questions that can be addressed, ultimately enabling the development of therapies to target dysfunctional signaling in human disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Unknown (R35)
Project #
3R35GM128648-02S1
Application #
10133448
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Zhao, Xiaoli
Project Start
2018-08-01
Project End
2023-07-31
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
2
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Washington
Department
Chemistry
Type
Graduate Schools
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195