Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AG001136-17S1
Application #
2048615
Study Section
Special Emphasis Panel (NSS)
Project Start
1993-09-15
Project End
1998-06-30
Budget Start
1994-07-10
Budget End
1995-06-30
Support Year
17
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Pathology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
DeTure, M; Ko, L W; Yen, S et al. (2000) Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions. Brain Res 853:14-May
Nacharaju, P; Lewis, J; Easson, C et al. (1999) Accelerated filament formation from tau protein with specific FTDP-17 missense mutations. FEBS Lett 447:195-9
Yen, S H; Hutton, M; DeTure, M et al. (1999) Fibrillogenesis of tau: insights from tau missense mutations in FTDP-17. Brain Pathol 9:695-705
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Kenessey, A; Nacharaju, P; Ko, L W et al. (1997) Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration. J Neurochem 69:2026-38
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Ikonomovic, M D; Armstrong, D M; Yen, S H et al. (1995) Atomic force microscopy of paired helical filaments isolated from the autopsied brains of patients with Alzheimer's disease and immunolabeled against microtubule-associated protein tau. Am J Pathol 147:516-28
Kenessey, A; Yen, S H; Liu, W K et al. (1995) Detection of D-aspartate in tau proteins associated with Alzheimer paired helical filaments. Brain Res 675:183-9
Liu, W K; Williams, R T; Hall, F L et al. (1995) Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments. Am J Pathol 146:228-38

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