Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AG009801-02S1
Application #
3480335
Study Section
Immunobiology Study Section (IMB)
Project Start
1990-08-01
Project End
1995-07-31
Budget Start
1992-04-15
Budget End
1992-07-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Other Domestic Higher Education
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Miller, R A (2000) Effect of aging on T lymphocyte activation. Vaccine 18:1654-60
Tamir, A; Eisenbraun, M D; Garcia, G G et al. (2000) Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction. J Immunol 165:1243-51
Eisenbraun, M D; Tamir, A; Miller, R A (2000) Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset. J Immunol 164:6105-12
Telford, W G; Miller, R A (1999) Aging increases CD8 T cell apoptosis induced by hyperstimulation but decreases apoptosis induced by agonist withdrawal in mice. Cell Immunol 191:131-8
Kirk, C J; Miller, R A (1999) Age-sensitive and -insensitive pathways leading to JNK activation in mouse CD4(+) T-cells. Cell Immunol 197:83-90
Kirk, C J; Freilich, A M; Miller, R A (1999) Age-related decline in activation of JNK by TCR- and CD28-mediated signals in murine T-lymphocytes. Cell Immunol 197:75-82
Witkowski, J M; Miller, R A (1999) Calcium signal abnormalities in murine T lymphocytes that express the multidrug transporter P-glycoprotein. Mech Ageing Dev 107:165-80
Yang, D; Miller, R A (1999) Cluster formation by protein kinase Ctheta during murine T cell activation: effect of age. Cell Immunol 195:28-36
Tamir, A; Miller, R A (1999) Aging impairs induction of cyclin-dependent kinases and down-regulation of p27 in mouse CD4(+) cells. Cell Immunol 198:11-20
Kirk, C J; Miller, R A (1998) Analysis of Raf-1 activation in response to TCR activation and costimulation in murine T-lymphocytes: effect of age. Cell Immunol 190:33-42

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