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Kinana, Alfred D; Vargiu, Attilio V; May, Thithiwat et al. (2016) Aminoacyl ?-naphthylamides as substrates and modulators of AcrB multidrug efflux pump. Proc Natl Acad Sci U S A 113:1405-10
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Soparkar, Ketaki; Kinana, Alfred D; Weeks, Jon W et al. (2015) Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli. J Bacteriol 197:3255-64
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Nobre, Thatyane M; Martynowycz, Michael W; Andreev, Konstantin et al. (2015) Modification of Salmonella Lipopolysaccharides Prevents the Outer Membrane Penetration of Novobiocin. Biophys J 109:2537-2545
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Li, Xian-Zhi; Plésiat, Patrick; Nikaido, Hiroshi (2015) The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clin Microbiol Rev 28:337-418
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Vargiu, Attilio V; Ruggerone, Paolo; Opperman, Timothy J et al. (2014) Molecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitors. Antimicrob Agents Chemother 58:6224-34
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Sugawara, Etsuko; Nikaido, Hiroshi (2014) Properties of AdeABC and AdeIJK efflux systems of Acinetobacter baumannii compared with those of the AcrAB-TolC system of Escherichia coli. Antimicrob Agents Chemother 58:7250-7
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Kinana, Alfred D; Vargiu, Attilio V; Nikaido, Hiroshi (2013) Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB. Biochemistry 52:8342-51
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Sugawara, Etsuko; Nagano, Keiji; Nikaido, Hiroshi (2012) Alternative folding pathways of the major porin OprF of Pseudomonas aeruginosa. FEBS J 279:910-8
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Kim, Hong-Suk; Nikaido, Hiroshi (2012) Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coli. Biochemistry 51:4188-97
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Vargiu, Attilio V; Nikaido, Hiroshi (2012) Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations. Proc Natl Acad Sci U S A 109:20637-42
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