Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI012211-23
Application #
2059867
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1998-05-31
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Kalish, R S; Askenase, P W (1999) Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity. J Allergy Clin Immunol 103:192-9
Szczepanik, M; Ptak, W; Askenase, P W (1999) Role of interleukin-4 in down-regulation of contact sensitivity by gammadelta T cells from tolerized T-cell receptor alpha-/- mice. Immunology 98:63-70
Szczepanik, M; Lewis, J; Geba, G P et al. (1998) Positive regulatory gamma delta T cells in contact sensitivity: augmented responses by in vivo treatment with anti-gamma delta monoclonal antibody, or anti-V gamma 5 or V delta 4. Immunol Invest 27:1-15
Ushio, H; Tsuji, R F; Szczepanik, M et al. (1998) IL-12 reverses established antigen-specific tolerance of contact sensitivity by affecting costimulatory molecules B7-1 (CD80) and B7-2 (CD86). J Immunol 160:2080-8
Ptak, W; Paliwal, V; Bryniarski, K et al. (1998) Aggregated immunoglobulin protects immune T cells from suppression: dependence on isotype, Fc portion, and macrophage FcgammaR. Scand J Immunol 47:136-45
Szczepanik, M; Nowak, B; Askenase, P W et al. (1998) Cross-talk between gammadelta T lymphocytes and immune cells in humoral response. Immunology 95:612-7
Szczepanik, M; Anderson, L R; Ushio, H et al. (1997) Gamma/delta T cells from tolerized alpha/beta-TCR-deficient mice antigen specifically inhibit contact sensitivity in vivo and IFN-gamma production in vitro. Int Arch Allergy Immunol 113:373-5
Matsuda, H; Ushio, H; Geba, G P et al. (1997) Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies. J Immunol 158:2891-7
Geba, G P; Wegner, C D; Wolyniec, W W et al. (1997) Nonatopic asthma: in vivo airway hyperreactivity adoptively transferred to naive mice by THY-1(+) and B220(+) antigen-specific cells that lack surface expression of CD3. J Clin Invest 100:629-38
Tsuji, R F; Geba, G P; Wang, Y et al. (1997) Required early complement activation in contact sensitivity with generation of local C5-dependent chemotactic activity, and late T cell interferon gamma: a possible initiating role of B cells. J Exp Med 186:1015-26

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