Sex Hormone Regulation of the Mucosal Immune System

Wira, Charles Robert

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37AI013541-25
• Application #: 6682759
• Study Section: Special Emphasis Panel (NSS)
• Program Officer: Rothermel, Annette L
• Project Start: 1985-09-30
• Project End: 2005-12-31
• Budget Start: 2003-01-01
• Budget End: 2003-12-31
• Support Year: 25
• Fiscal Year: 2003
• Total Cost: $355,500

Institution

• Name: Dartmouth College
• Department: Physiology
• Type: Schools of Medicine
• DUNS #: 041027822
• City: Hanover
• State: NH
• Country: United States
• Zip Code: 03755

Publications

Shen, Zheng; Fahey, John V; Bodwell, Jack E et al. (2014) Sex hormones regulate tenofovir-diphosphate in female reproductive tract cells in culture. PLoS One 9:e100863

Haddad, Severina N; Wira, Charles R (2014) Estradiol regulation of constitutive and keratinocyte growth factor-induced CCL20 and CXCL1 secretion by mouse uterine epithelial cells. Am J Reprod Immunol 72:34-44

Patel, Mickey V; Ghosh, Mimi; Fahey, John V et al. (2014) Innate immunity in the vagina (Part II): Anti-HIV activity and antiviral content of human vaginal secretions. Am J Reprod Immunol 72:22-33

Rodriguez-Garcia, Marta; Biswas, Nabanita; Patel, Mickey V et al. (2013) Estradiol reduces susceptibility of CD4+ T cells and macrophages to HIV-infection. PLoS One 8:e62069

Rodriguez-Garcia, Marta; Patel, Mickey V; Wira, Charles R (2013) Innate and adaptive anti-HIV immune responses in the female reproductive tract. J Reprod Immunol 97:74-84

Biswas, Nabanita; Rodriguez-Garcia, Marta; Crist, Sarah G et al. (2013) Effect of tenofovir on nucleotidases and cytokines in HIV-1 target cells. PLoS One 8:e78814

Patel, Mickey V; Fahey, John V; Rossoll, Richard M et al. (2013) Innate immunity in the vagina (part I): estradiol inhibits HBD2 and elafin secretion by human vaginal epithelial cells. Am J Reprod Immunol 69:463-74

Coleman, Kimberly D; Ghosh, Mimi; Crist, Sarah G et al. (2012) Modulation of hepatocyte growth factor secretion in human female reproductive tract stromal fibroblasts by poly (I:C) and estradiol. Am J Reprod Immunol 67:44-53

Lahey, Timothy; Ghosh, Mimi; Fahey, John V et al. (2012) Selective impact of HIV disease progression on the innate immune system in the human female reproductive tract. PLoS One 7:e38100

Ochiel, Daniel O; Rossoll, Richard M; Schaefer, Todd M et al. (2012) Effect of oestradiol and pathogen-associated molecular patterns on class II-mediated antigen presentation and immunomodulatory molecule expression in the mouse female reproductive tract. Immunology 135:51-62