Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI013587-21
Application #
2060003
Study Section
Special Emphasis Panel (NSS)
Project Start
1994-05-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Belmares, Michael P; Busch, Robert; Mellins, Elizabeth D et al. (2003) Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DM. Biochemistry 42:838-47
Belmares, Michael P; Busch, Robert; Wucherpfennig, Kai W et al. (2002) Structural factors contributing to DM susceptibility of MHC class II/peptide complexes. J Immunol 169:5109-17
Anderson, Thomas G; McConnell, Harden M (2002) A thermodynamic model for extended complexes of cholesterol and phospholipid. Biophys J 83:2039-52
Anderson, T G; McConnell, H M (2001) Condensed complexes and the calorimetry of cholesterol-phospholipid bilayers. Biophys J 81:2774-85
Schmitt, L; Boniface, J J; Davis, M M et al. (1999) Conformational isomers of a class II MHC-peptide complex in solution. J Mol Biol 286:207-18
Lee, C; Liang, M N; Tate, K M et al. (1998) Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft. J Exp Med 187:1505-16
Rabinowitz, J D; Rigler, P; Carswell-Crumpton, C et al. (1997) Screening for novel drug effects with a microphysiometer: a potent effect of clofilium unrelated to potassium channel blockade. Life Sci 61:PL87-94
Liang, M N; Lee, C; Xia, Y et al. (1996) Molecular modeling and design of invariant chain peptides with altered dissociation kinetics from class II MHC. Biochemistry 35:14734-42
Mason, K; Denney Jr, D W; McConnell, H M (1995) Kinetics of the reaction of a myelin basic protein peptide with soluble IAu. Biochemistry 34:14874-8
Mason, K; Denney Jr, D W; McConnell, H M (1995) Myelin basic protein peptide complexes with the class II MHC molecules I-Au and I-Ak form and dissociate rapidly at neutral pH. J Immunol 154:5216-27

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