Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI013989-20
Application #
2060034
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-04-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wistar Institute
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Mozdzanowska, Krystyna; Feng, Jingqi; Eid, Mark et al. (2006) Enhancement of neutralizing activity of influenza virus-specific antibodies by serum components. Virology 352:418-26
Mozdzanowska, Krystyna; Furchner, Michelle; Zharikova, Darya et al. (2005) Roles of CD4+ T-cell-independent and -dependent antibody responses in the control of influenza virus infection: evidence for noncognate CD4+ T-cell activities that enhance the therapeutic activity of antiviral antibodies. J Virol 79:5943-51
Zharikova, Darya; Mozdzanowska, Krystyna; Feng, Jingqi et al. (2005) Influenza type A virus escape mutants emerge in vivo in the presence of antibodies to the ectodomain of matrix protein 2. J Virol 79:6644-54
Mozdzanowska, Krystyna; Feng, JinQi; Eid, Mark et al. (2003) Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2. Vaccine 21:2616-26
Feng, Jing Qi; Mozdzanowska, Krystyna; Gerhard, Walter (2002) Complement component C1q enhances the biological activity of influenza virus hemagglutinin-specific antibodies depending on their fine antigen specificity and heavy-chain isotype. J Virol 76:1369-78
Mozdzanowska, K; Maiese, K; Gerhard, W (2000) Th cell-deficient mice control influenza virus infection more effectively than Th- and B cell-deficient mice: evidence for a Th-independent contribution by B cells to virus clearance. J Immunol 164:2635-43
Mozdzanowska, K; Maiese, K; Furchner, M et al. (1999) Treatment of influenza virus-infected SCID mice with nonneutralizing antibodies specific for the transmembrane proteins matrix 2 and neuraminidase reduces the pulmonary virus titer but fails to clear the infection. Virology 254:138-46
Mozdzanowska, K; Furchner, M; Washko, G et al. (1997) A pulmonary influenza virus infection in SCID mice can be cured by treatment with hemagglutinin-specific antibodies that display very low virus-neutralizing activity in vitro. J Virol 71:4347-55
Mozdzanowska, K; Furchner, M; Maiese, K et al. (1997) CD4+ T cells are ineffective in clearing a pulmonary infection with influenza type A virus in the absence of B cells. Virology 239:217-25
Gerhard, W; Mozdzanowska, K; Furchner, M et al. (1997) Role of the B-cell response in recovery of mice from primary influenza virus infection. Immunol Rev 159:95-103

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