Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AI015607-13S1
Application #
3480832
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1979-01-01
Project End
1993-08-31
Budget Start
1993-06-01
Budget End
1993-08-31
Support Year
13
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Szalai, A J; Agrawal, A; Greenhough, T J et al. (1999) C-reactive protein: structural biology and host defense function. Clin Chem Lab Med 37:265-70
Szalai, A J; van Ginkel, F W; Dalrymple, S A et al. (1998) Testosterone and IL-6 requirements for human C-reactive protein gene expression in transgenic mice. J Immunol 160:5294-9
Agrawal, A; Lee, S; Carson, M et al. (1997) Site-directed mutagenesis of the phosphocholine-binding site of human C-reactive protein: role of Thr76 and Trp67. J Immunol 158:345-50
Szalai, A J; Briles, D E; Volanakis, J E (1996) Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae. Infect Immun 64:4850-3
Szalai, A J; Briles, D E; Volanakis, J E (1995) Human C-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice. J Immunol 155:2557-63
Agrawal, A; Volanakis, J E (1994) Probing the C1q-binding site on human C-reactive protein by site-directed mutagenesis. J Immunol 152:5404-10
Agrawal, A; Xu, Y; Ansardi, D et al. (1992) Probing the phosphocholine-binding site of human C-reactive protein by site-directed mutagenesis. J Biol Chem 267:25353-8
Kilpatrick, J M; Gresham, H D; Griffin Jr, F M et al. (1987) Peripheral blood mononuclear leukocytes release a mediator(s) that induces phagocytosis of C-reactive protein-coated cells by polymorphonuclear leukocytes. J Leukoc Biol 41:150-5
Horowitz, J; Volanakis, J E; Briles, D E (1987) Blood clearance of Streptococcus pneumoniae by C-reactive protein. J Immunol 138:2598-603
Gresham, H D; Clement, L T; Lehmeyer, J E et al. (1986) Stimulation of human neutrophil Fc receptor-mediated phagocytosis by a low molecular weight cytokine. J Immunol 137:868-75

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