Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI015650-19
Application #
2060268
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1979-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Illinois Urbana-Champaign
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820

  Publications

Cronan, John E (2018) Advances in synthesis of biotin and assembly of lipoic acid. Curr Opin Chem Biol 47:60-66
Manandhar, Miglena; Cronan, John E (2018) A Canonical Biotin Synthesis Enzyme, 8-Amino-7-Oxononanoate Synthase (BioF), Utilizes Different Acyl Chain Donors in Bacillus subtilis and Escherichia coli. Appl Environ Microbiol 84:
Cao, Xinyun; Zhu, Lei; Song, Xuejiao et al. (2018) Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes. Proc Natl Acad Sci U S A 115:E7063-E7072
Srinivas, Swaminath; Cronan, John E (2017) An Eight-Residue Deletion in Escherichia coli FabG Causes Temperature-Sensitive Growth and Lipid Synthesis Plus Resistance to the Calmodulin Inhibitor Trifluoperazine. J Bacteriol 199:
Manandhar, Miglena; Cronan, John E (2017) Pimelic acid, the first precursor of the Bacillus subtilis biotin synthesis pathway, exists as the free acid and is assembled by fatty acid synthesis. Mol Microbiol 104:595-607
Cao, Xinyun; Zhu, Lei; Hu, Zhe et al. (2017) Expression and Activity of the BioH Esterase of Biotin Synthesis is Independent of Genome Context. Sci Rep 7:2141
Bi, Hongkai; Zhu, Lei; Jia, Jia et al. (2016) A Biotin Biosynthesis Gene Restricted to Helicobacter. Sci Rep 6:21162
Henke, Sarah K; Cronan, John E (2016) The Staphylococcus aureus group II biotin protein ligase BirA is an effective regulator of biotin operon transcription and requires the DNA binding domain for full enzymatic activity. Mol Microbiol 102:417-429
Cronan, John E (2016) pBR322 vectors having tetracycline-dependent replication. Plasmid 84-85:20-6
Bi, Hongkai; Zhu, Lei; Jia, Jia et al. (2016) Unsaturated Fatty Acid Synthesis in the Gastric Pathogen Helicobacter pylori Proceeds via a Backtracking Mechanism. Cell Chem Biol 23:1480-1489

Showing the most recent 10 out of 157 publications