Abstract

Nude mice congenic to several inbred mouse strains will be produced. These mice will be maintained in germ-free and specific pathogen-free colonies. They will be used for an analysis of B-cell development. The relationships between lymphocytes capable of responding to certain thymus independent antigens and those capable of responding to thymus dependent antigens will be investigated. The role of antigen-antibody complexes in this relationship will be studied. In particular, the idea that there is immunoglobulin isotype specific regulation of the immune response will be tested.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI015803-12
Application #
3480868
Study Section
Immunological Sciences Study Section (IMS)
Project Start
1979-05-01
Project End
1992-04-30
Budget Start
1990-05-01
Budget End
1991-04-30
Support Year
12
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Tufts University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Berland, Robert; Wortis, Henry H (2003) Normal B-1a cell development requires B cell-intrinsic NFATc1 activity. Proc Natl Acad Sci U S A 100:13459-64
Jin, Lei; McLean, Paul A; Neel, Benjamin G et al. (2002) Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling. J Exp Med 195:1199-205
Ma, Limei; Wortis, Henry H; Kenter, Amy L (2002) Two new isotype-specific switching activities detected for Ig class switching. J Immunol 168:2835-46
Wortis, H H; Berland, R (2001) Cutting edge commentary: origins of B-1 cells. J Immunol 166:2163-6
Berland, R; Wortis, H H (2000) Role of NFAT in the regulation of B-1 cells. Curr Top Microbiol Immunol 252:131-40
Bajpai, U D; Zhang, K; Teutsch, M et al. (2000) Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med 191:1735-44
Doody, G M; Billadeau, D D; Clayton, E et al. (2000) Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes. EMBO J 19:6173-84
Novina, C D; Kumar, S; Bajpai, U et al. (1999) Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase. Mol Cell Biol 19:5014-24
Berland, R; Wortis, H H (1998) An NFAT-dependent enhancer is necessary for anti-IgM-mediated induction of murine CD5 expression in primary splenic B cells. J Immunol 161:277-85
Lin, S C; Wortis, H H; Stavnezer, J (1998) The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteins. Mol Cell Biol 18:5523-32

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