Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI018188-16
Application #
2060649
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1981-08-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Shao, Baomei; Munford, Robert S; Kitchens, Richard et al. (2012) Hepatic uptake and deacylation of the LPS in bloodborne LPS-lipoprotein complexes. Innate Immun 18:825-33
Shao, Baomei; Kitchens, Richard L; Munford, Robert S et al. (2011) Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin. Hepatology 54:1051-62
Lu, Mingfang; Munford, Robert S (2011) The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo. J Immunol 187:3314-20
Ojogun, Noredia; Kuang, Tang-Yong; Shao, Baomei et al. (2009) Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo. J Infect Dis 200:1685-93
Munford, Robert; Lu, Mingfang; Varley, Alan (2009) Chapter 2: Kill the bacteria...and also their messengers? Adv Immunol 103:29-48
Gioannini, Theresa L; Teghanemt, Athmane; Zhang, DeSheng et al. (2007) Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase. J Biol Chem 282:7877-84
Shao, Baomei; Lu, Mingfang; Katz, Steven C et al. (2007) A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen. J Biol Chem 282:13726-35
Munford, Robert S; Varley, Alan W (2006) Shield as signal: lipopolysaccharides and the evolution of immunity to gram-negative bacteria. PLoS Pathog 2:e67
Lu, Mingfang; Zhang, Mei; Takashima, Akira et al. (2005) Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria. Nat Immunol 6:989-94
Feulner, J Amelia; Lu, Mingfang; Shelton, John M et al. (2004) Identification of acyloxyacyl hydrolase, a lipopolysaccharide-detoxifying enzyme, in the murine urinary tract. Infect Immun 72:3171-8

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