Infections caused by herpes simplex viruses remain major health problems in the U.S. The genital form, HSV2 facilitates spread of HIV-AIDS. An effective vaccine against HSV2 is urgently needed. HSV uses 4 proteins, gB, gD and a gH/gL complex to invade cells. We will study how they work together and how the host responds with the long term goal of making effective vaccines and new therapeutics.
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