Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI018895-15
Application #
2060806
Study Section
Special Emphasis Panel (NSS)
Project Start
1989-01-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Oklahoma Health Sciences Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
McGaha, T; Murphy, J W (2000) CTLA-4 down-regulates the protective anticryptococcal cell-mediated immune response. Infect Immun 68:4624-30
Doyle, H A; Murphy, J W (1999) Role of the C-C chemokine, TCA3, in the protective anticryptococcal cell-mediated immune response. J Immunol 162:4824-33
Blackstock, R; Buchanan, K L; Adesina, A M et al. (1999) Differential regulation of immune responses by highly and weakly virulent Cryptococcus neoformans isolates. Infect Immun 67:3601-9
Dong, Z M; Jackson, L; Murphy, J W (1999) Mechanisms for induction of L-selectin loss from T lymphocytes by a cryptococcal polysaccharide, glucuronoxylomannan. Infect Immun 67:220-9
Murphy, J W; Schafer, F; Casadevall, A et al. (1998) Antigen-induced protective and nonprotective cell-mediated immune components against Cryptococcus neoformans. Infect Immun 66:2632-9
Dong, Z M; Murphy, J W (1997) Cryptococcal polysaccharides bind to CD18 on human neutrophils. Infect Immun 65:557-63
Murphy, J W; Zhou, A; Wong, S C (1997) Direct interactions of human natural killer cells with Cryptococcus neoformans inhibit granulocyte-macrophage colony-stimulating factor and tumor necrosis factor alpha production. Infect Immun 65:4564-71
Dong, Z M; Murphy, J W (1996) Cryptococcal polysaccharides induce L-selectin shedding and tumor necrosis factor receptor loss from the surface of human neutrophils. J Clin Invest 97:689-98
Muth, S M; Murphy, J W (1995) Direct anticryptococcal activity of lymphocytes from Cryptococcus neoformans-immunized mice. Infect Immun 63:1637-44
Levitz, S M; Mathews, H L; Murphy, J W (1995) Direct antimicrobial activity of T cells. Immunol Today 16:387-91

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