Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI018939-13
Application #
2060816
Study Section
Special Emphasis Panel (NSS)
Project Start
1984-09-30
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
13
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201
Eggel, Alexander; Baravalle, Günther; Hobi, Gabriel et al. (2014) Accelerated dissociation of IgE-Fc?RI complexes by disruptive inhibitors actively desensitizes allergic effector cells. J Allergy Clin Immunol 133:1709-19.e8
Kim, Beomkyu; Tarchevskaya, Svetlana S; Eggel, Alexander et al. (2012) A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions. Anal Biochem 431:84-9
Wurzburg, Beth A; Kim, Beomkyu; Tarchevskaya, Svetlana S et al. (2012) An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, nonreceptor binding conformation. J Biol Chem 287:36251-7
Kim, Beomkyu; Eggel, Alexander; Tarchevskaya, Svetlana S et al. (2012) Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor. Nature 491:613-7
Wurzburg, Beth A; Jardetzky, Theodore S (2009) Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms. J Mol Biol 393:176-90
Cheng, P C; Brown, B K; Song, W et al. (2001) Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling. J Immunol 166:3693-701
Sproul, T W; Malapati, S; Kim, J et al. (2000) Cutting edge: B cell antigen receptor signaling occurs outside lipid rafts in immature B cells. J Immunol 165:6020-3
Wagle, N M; Kim, J H; Pierce, S K (1999) CD19 regulates B cell antigen receptor-mediated MHC class II antigen processing. Vaccine 18:376-86
Cheng, P C; Dykstra, M L; Mitchell, R N et al. (1999) A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J Exp Med 190:1549-60
Cheng, P C; Steele, C R; Gu, L et al. (1999) MHC class II antigen processing in B cells: accelerated intracellular targeting of antigens. J Immunol 162:7171-80

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