Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI020566-14
Application #
2061271
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1983-12-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Harvard University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Zhao, Zhao; Zhang, Meng; Hogle, James M et al. (2018) DNA-Corralled Nanodiscs for the Structural and Functional Characterization of Membrane Proteins and Viral Entry. J Am Chem Soc 140:10639-10643
Nasr, Mahmoud L; Baptista, Diego; Strauss, Mike et al. (2017) Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nat Methods 14:49-52
Strauss, Mike; Schotte, Lise; Karunatilaka, Krishanthi S et al. (2017) Cryo-electron Microscopy Structures of Expanded Poliovirus with VHHs Sample the Conformational Repertoire of the Expanded State. J Virol 91:
Strauss, Mike; Schotte, Lise; Thys, Bert et al. (2016) Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site. J Virol 90:3496-505
Schotte, Lise; Thys, Bert; Strauss, Mike et al. (2015) Characterization of Poliovirus Neutralization Escape Mutants of Single-Domain Antibody Fragments (VHHs). Antimicrob Agents Chemother 59:4695-706
Strauss, Mike; Filman, David J; Belnap, David M et al. (2015) Nectin-like interactions between poliovirus and its receptor trigger conformational changes associated with cell entry. J Virol 89:4143-57
Schotte, Lise; Strauss, Mike; Thys, Bert et al. (2014) Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity. J Virol 88:4403-13
Butan, Carmen; Filman, David J; Hogle, James M (2014) Cryo-electron microscopy reconstruction shows poliovirus 135S particles poised for membrane interaction and RNA release. J Virol 88:1758-70
Strauss, Mike; Levy, Hazel C; Bostina, Mihnea et al. (2013) RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors. J Virol 87:3903-14
Levy, Hazel C; Bostina, Mihnea; Filman, David J et al. (2010) Catching a virus in the act of RNA release: a novel poliovirus uncoating intermediate characterized by cryo-electron microscopy. J Virol 84:4426-41

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