Glycoconjugates of Leishmania

Turco, Salvatore J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37AI020941-12
• Application #: 2061360
• Study Section: Tropical Medicine and Parasitology Study Section (TMP)
• Project Start: 1985-09-01
• Project End: 1998-08-31
• Budget Start: 1996-09-01
• Budget End: 1997-08-31
• Support Year: 12
• Fiscal Year: 1996

Institution

• Name: University of Kentucky
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 832127323
• City: Lexington
• State: KY
• Country: United States
• Zip Code: 40506

Publications

Phillips, Megan R; Turco, Salvatore J (2015) Characterization of a ricin-resistant mutant of Leishmania donovani that expresses lipophosphoglycan. Glycobiology 25:428-37

Soares, Rodrigo P; Margonari, Carina; Secundino, Nagila C et al. (2010) Differential midgut attachment of Leishmania (Viannia) braziliensis in the sand flies Lutzomyia (Nyssomyia) whitmani and Lutzomyia (Nyssomyia) intermedia. J Biomed Biotechnol 2010:439174

Dobson, Deborah E; Kamhawi, Shaden; Lawyer, Phillip et al. (2010) Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern. PLoS Pathog 6:e1001185

Dobson, Deborah E; Scholtes, Luella D; Myler, Peter J et al. (2006) Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications. Mol Biochem Parasitol 146:231-41

Barron, Tamara L; Turco, Salvatore J (2006) Quantitation of Leishmania lipophosphoglycan repeat units by capillary electrophoresis. Biochim Biophys Acta 1760:710-4

Goswami, Mamta; Dobson, Deborah E; Beverley, Stephen M et al. (2006) Demonstration by heterologous expression that the Leishmania SCA1 gene encodes an arabinopyranosyltransferase. Glycobiology 16:230-6

Segawa, Hiroaki; Soares, Rodrigo P; Kawakita, Masao et al. (2005) Reconstitution of GDP-mannose transport activity with purified Leishmania LPG2 protein in liposomes. J Biol Chem 280:2028-35

Dermine, Jean-Francois; Goyette, Guillaume; Houde, Mathieu et al. (2005) Leishmania donovani lipophosphoglycan disrupts phagosome microdomains in J774 macrophages. Cell Microbiol 7:1263-70

Soares, Rodrigo P P; Cardoso, Tatiana L; Barron, Tamara et al. (2005) Leishmania braziliensis: a novel mechanism in the lipophosphoglycan regulation during metacyclogenesis. Int J Parasitol 35:245-53

Colmenares, Maria; Corbi, Angel L; Turco, Salvatore J et al. (2004) The dendritic cell receptor DC-SIGN discriminates among species and life cycle forms of Leishmania. J Immunol 172:1186-90