Plasmid PCD-1 Encoded Virulence Determinants

Straley, Susan C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37AI021017-19
• Application #: 6497233
• Study Section: Special Emphasis Panel (NSS)
• Program Officer: Baker, Phillip J
• Project Start: 1983-09-01
• Project End: 2005-01-31
• Budget Start: 2002-02-01
• Budget End: 2003-01-31
• Support Year: 19
• Fiscal Year: 2002
• Total Cost: $369,657

Institution

• Name: University of Kentucky
• Department: Microbiology/Immun/Virology
• Type: Schools of Medicine
• DUNS #: 832127323
• City: Lexington
• State: KY
• Country: United States
• Zip Code: 40506

Publications

Fowler, Janet M; Wulff, Christine R; Straley, Susan C et al. (2009) Growth of calcium-blind mutants of Yersinia pestis at 37 degrees C in permissive Ca2+-deficient environments. Microbiology 155:2509-21

Philipovskiy, Alexander V; Cowan, Clarissa; Wulff-Strobel, Christine R et al. (2005) Antibody against V antigen prevents Yop-dependent growth of Yersinia pestis. Infect Immun 73:1532-42

Cowan, Clarissa; Philipovskiy, Alexander V; Wulff-Strobel, Christine R et al. (2005) Anti-LcrV antibody inhibits delivery of Yops by Yersinia pestis KIM5 by directly promoting phagocytosis. Infect Immun 73:6127-37

Wulff-Strobel, Christine R; Williams, Andrew W; Straley, Susan C (2002) LcrQ and SycH function together at the Ysc type III secretion system in Yersinia pestis to impose a hierarchy of secretion. Mol Microbiol 43:411-23

Cowan, C; Jones, H A; Kaya, Y H et al. (2000) Invasion of epithelial cells by Yersinia pestis: evidence for a Y. pestis-specific invasin. Infect Immun 68:4523-30

Fields, K A; Straley, S C (1999) LcrV of Yersinia pestis enters infected eukaryotic cells by a virulence plasmid-independent mechanism. Infect Immun 67:4801-13

Payne, P L; Straley, S C (1999) YscP of Yersinia pestis is a secreted component of the Yop secretion system. J Bacteriol 181:2852-62

Fields, K A; Nilles, M L; Cowan, C et al. (1999) Virulence role of V antigen of Yersinia pestis at the bacterial surface. Infect Immun 67:5395-408

Payne, P L; Straley, S C (1998) YscO of Yersinia pestis is a mobile core component of the Yop secretion system. J Bacteriol 180:3882-90

Williams, A W; Straley, S C (1998) YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops. J Bacteriol 180:350-8