Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI021372-23
Application #
7055318
Study Section
Special Emphasis Panel (NSS)
Program Officer
Macchiarini, Francesca
Project Start
1984-07-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
23
Fiscal Year
2006
Total Cost
$366,888
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
D'Souza, Warren N; Hedrick, Stephen M (2006) Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. J Immunol 177:777-81
McGargill, Maureen A; Sharp, Leslie L; Bui, Jack D et al. (2005) Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling. J Immunol 175:656-64
Catlett, Ian M; Hedrick, Stephen M (2005) Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells. Nat Immunol 6:715-21
Fischer, April M; Katayama, Carol D; Pages, Giles et al. (2005) The role of erk1 and erk2 in multiple stages of T cell development. Immunity 23:431-43
Soloff, Rachel S; Katayama, Carol; Lin, Meei Yun et al. (2004) Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J Immunol 173:3250-60
Page, D M (1999) Cutting edge: thymic selection and autoreactivity are regulated by multiple coreceptors involved in T cell activation. J Immunol 163:3577-81
Sharp, L L; Hedrick, S M (1999) Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and lck signaling. J Immunol 163:6598-605
Hedrick, S M; Sharp, L L (1998) T-cell fate. Immunol Rev 165:95-110
Sharp, L L; Schwarz, D A; Bott, C M et al. (1997) The influence of the MAPK pathway on T cell lineage commitment. Immunity 7:609-18
Kersh, G J; Hooshmand, F F; Hedrick, S M (1995) Efficient maturation of alpha beta lineage thymocytes to the CD4+CD8+ stage in the absence of TCR-beta rearrangement. J Immunol 154:5706-14

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