Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI021451-26
Application #
8238385
Study Section
Special Emphasis Panel (NSS)
Program Officer
Taylor, Christopher E,
Project Start
1984-08-01
Project End
2015-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
26
Fiscal Year
2012
Total Cost
$419,513
Indirect Cost
$172,013
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Han, Kook; Tjaden, Brian; Lory, Stephen (2016) GRIL-seq provides a method for identifying direct targets of bacterial small regulatory RNA by in vivo proximity ligation. Nat Microbiol 2:16239
Caille, Olivier; Zincke, Diansy; Merighi, Massimo et al. (2014) Structural and functional characterization of Pseudomonas aeruginosa global regulator AmpR. J Bacteriol 196:3890-902
Cattoir, V; Narasimhan, G; Skurnik, D et al. (2013) Transcriptional response of mucoid Pseudomonas aeruginosa to human respiratory mucus. MBio 3:e00410-12
Skurnik, David; Roux, Damien; Cattoir, Vincent et al. (2013) Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing. Proc Natl Acad Sci U S A 110:20747-52
Skurnik, David; Roux, Damien; Aschard, Hugues et al. (2013) A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries. PLoS Pathog 9:e1003582
Mulcahy, Lawrence R; Burns, Jane L; Lory, Stephen et al. (2010) Emergence of Pseudomonas aeruginosa strains producing high levels of persister cells in patients with cystic fibrosis. J Bacteriol 192:6191-9
Hurley, Bryan P; Goodman, Andrew L; Mumy, Karen L et al. (2010) The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cells. Microbes Infect 12:190-8
Koh, Andrew Y; Mikkelsen, Per J; Smith, Roger S et al. (2010) Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination. PLoS One 5:e15131
Thaden, Joshua T; Lory, Stephen; Gardner, Timothy S (2010) Quorum-sensing regulation of a copper toxicity system in Pseudomonas aeruginosa. J Bacteriol 192:2557-68
Lory, Stephen; Merighi, Massimo; Hyodo, Mamoru (2009) Multiple activities of c-di-GMP in Pseudomonas aeruginosa. Nucleic Acids Symp Ser (Oxf) :51-2

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