Abstract

Among recent Haitian emigrants living in Miami the prevalence of serum antibodies to HTLV-III/LAV is 2-9%. Haitian-born women deliver between 2200 and 2500 infants annually at Jackson Memorial Hospital in Miami; approximately 20 of these infants will develop clinical evidence of HTLV-III/LAV infection each year. These deliveries constitute at least 90% of all births among Haitian emigrants in Dade County. We propose to determine the proportion of seropositive mothers that give birth to seropositive, virus-positive infants that develop clinical syndromes associated with HTLV-III/LAV infection. Seropositive and seronegative infants of seropositive mothers will be followed with a comparable number of seronegative infants of seronegative mothers for two years to assess their outcome. Information obtained from this population-based study will be of significance in two major areas. First, the information from the mothers will be used to assess the risks to unborn infants of women with HTLV-III/LAV infection. Second, the population-based character of the study will provide more complete information on the clinical spectrum of HTLV-III/LAV infection among infants in this population.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
1R37AI023524-01
Application #
3481244
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1986-03-01
Project End
1991-02-28
Budget Start
1986-03-01
Budget End
1987-02-28
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33101

  Publications

Fletcher, M; Miguez-Burbano, M J; Shor-Posner, G et al. (2000) Diagnosis of human immunodeficiency virus infection using an immunoglobulin E-based assay. Clin Diagn Lab Immunol 7:55-7
Geffin, R B; Scott, G B; Melenwick, M et al. (1998) Association of antibody reactivity to ELDKWA, a glycoprotein 41 neutralization epitope, with disease progression in children perinatally infected with HIV type 1. AIDS Res Hum Retroviruses 14:579-90
Unal, A; Lorenzo, E; Brown, M et al. (1996) Reverse transcriptase mutations in HIV-1-infected children treated with zidovudine. J Acquir Immune Defic Syndr Hum Retrovirol 13:140-5
McLaughlin, G E; Virdee, S S; Schleien, C L et al. (1995) Effect of corticosteroids on survival of children with acquired immunodeficiency syndrome and Pneumocystis carinii-related respiratory failure. J Pediatr 126:821-4
Gay, C L; Armstrong, F D; Cohen, D et al. (1995) The effects of HIV on cognitive and motor development in children born to HIV-seropositive women with no reported drug use: birth to 24 months. Pediatrics 96:1078-82
Duiculescu, D C; Geffin, R B; Scott, G B et al. (1994) Clinical and immunological correlates of immune-complex-dissociated HIV-1 p24 antigen in HIV-1-infected children. J Acquir Immune Defic Syndr 7:807-15
Geffin, R B; Lai, S H; Hutto, C et al. (1992) Quantitative analysis of human immunodeficiency virus type 1 antibody reactivity by western immunoblots: evaluation of relative antibody levels in seropositive individuals and mothers. J Infect Dis 165:111-8
Kaoma, F M; Scott, G B (1992) Clinical manifestations, management and therapy of HIV infection in children. Baillieres Clin Obstet Gynaecol 6:149-64
Khouri, Y F; Mastrucci, M T; Hutto, C et al. (1992) Mycobacterium tuberculosis in children with human immunodeficiency virus type 1 infection. Pediatr Infect Dis J 11:950-5
Mitchell, C D; Erlich, S S; Mastrucci, M T et al. (1990) Congenital toxoplasmosis occurring in infants perinatally infected with human immunodeficiency virus 1. Pediatr Infect Dis J 9:512-8

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