Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI024739-06
Application #
3481299
Study Section
Special Emphasis Panel (NSS)
Project Start
1987-04-01
Project End
1997-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Lokki, M L; Circolo, A; Ahokas, P et al. (1999) Deficiency of human complement protein C4 due to identical frameshift mutations in the C4A and C4B genes. J Immunol 162:3687-93
Wang, X; Circolo, A; Lokki, M L et al. (1998) Molecular heterogeneity in deficiency of complement protein C2 type I. Immunology 93:184-91
Matsumoto, M; Fukuda, W; Circolo, A et al. (1997) Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc Natl Acad Sci U S A 94:8720-5
Singer, L; Van Hee, M L; Lokki, M L et al. (1996) Inherited complement C3 deficiency: reduced C3 mRNA and protein levels in a Laotian kindred. Clin Immunol Immunopathol 81:244-52
Wetsel, R A; Kulics, J; Lokki, M L et al. (1996) Type II human complement C2 deficiency. Allele-specific amino acid substitutions (Ser189 --> Phe;Gly444 --> Arg) cause impaired C2 secretion. J Biol Chem 271:5824-31
Garnier, G; Circolo, A; Colten, H R (1996) Constitutive expression of murine complement factor B gene is regulated by the interaction of its upstream promoter with hepatocyte nuclear factor 4. J Biol Chem 271:30205-11
Garnier, G; Circolo, A; Colten, H R (1995) Translational regulation of murine complement factor B alternative transcripts by upstream AUG codons. J Immunol 154:3275-82
Singer, L; Whitehead, W T; Akama, H et al. (1994) Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (ASP549 to ASN) impairs C3 secretion. J Biol Chem 269:28494-9
Kulics, J; Circolo, A; Strunk, R C et al. (1994) Regulation of synthesis of complement protein C4 in human fibroblasts: cell- and gene-specific effects of cytokines and lipopolysaccharide. Immunology 82:509-15
Johnson, C A; Densen, P; Hurford Jr, R K et al. (1992) Type I human complement C2 deficiency. A 28-base pair gene deletion causes skipping of exon 6 during RNA splicing. J Biol Chem 267:9347-53

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