Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI025082-16
Application #
6700217
Study Section
Special Emphasis Panel (NSS)
Program Officer
Plaut, Marshall
Project Start
1989-08-01
Project End
2008-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
16
Fiscal Year
2004
Total Cost
$378,300
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Jiang, Xiaodong; Clark, Rachael A; Liu, Luzheng et al. (2012) Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature 483:227-31
Clark, Rachael A; Watanabe, Rei; Teague, Jessica E et al. (2012) Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci Transl Med 4:117ra7
Liu, Luzheng; Zhong, Qiong; Tian, Tian et al. (2010) Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity. Nat Med 16:224-7
Jiang, Xiaodong; Campbell, James J; Kupper, Thomas S (2010) Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4. Proc Natl Acad Sci U S A 107:7443-8
Clark, Rachael A; Chong, Benjamin F; Mirchandani, Nina et al. (2006) A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol 126:1059-70
Clark, Rachael A; Chong, Benjamin; Mirchandani, Nina et al. (2006) The vast majority of CLA+ T cells are resident in normal skin. J Immunol 176:4431-9
Clark, Rachael A; Kupper, Thomas S (2006) Misbehaving macrophages in the pathogenesis of psoriasis. J Clin Invest 116:2084-7
Clark, Rachael A; Yamanaka, Kei-ichi; Bai, Mei et al. (2005) Human skin cells support thymus-independent T cell development. J Clin Invest 115:3239-49
Robert, C; Klein, C; Cheng, G et al. (2003) Gene therapy to target dendritic cells from blood to lymph nodes. Gene Ther 10:1479-86