Oxidative Neutrophil Microbicidal Mechanisms

Rosen, Henry

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37AI025606-07
• Application #: 3481322
• Study Section: Bacteriology and Mycology Subcommittee 2 (BM)
• Project Start: 1988-03-01
• Project End: 1994-08-31
• Budget Start: 1994-03-01
• Budget End: 1994-08-31
• Support Year: 7
• Fiscal Year: 1994

Institution

• Name: Swedish Medical Center, First Hill
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98122

Publications

Rosen, Henry; Klebanoff, Seymour J; Wang, Yi et al. (2009) Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils. Proc Natl Acad Sci U S A 106:18686-91

Rosen, Henry; Crowley, Jan R; Heinecke, Jay W (2002) Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis. J Biol Chem 277:30463-8

Staudinger, Benjamin J; Oberdoerster, Michele A; Lewis, Patrick J et al. (2002) mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils. J Clin Invest 110:1151-63

Rosen, H; Michel, B R; vanDevanter, D R et al. (1998) Differential effects of myeloperoxidase-derived oxidants on Escherichia coli DNA replication. Infect Immun 66:2655-9

Kuhl, S J; Rosen, H (1998) Nitric oxide and septic shock. From bench to bedside. West J Med 168:176-81

Rosen, H; Michel, B R (1997) Redundant contribution of myeloperoxidase-dependent systems to neutrophil-mediated killing of Escherichia coli. Infect Immun 65:4173-8

Rosen, H (1997) Superantigens. Int J Dermatol 36:14-6

Durden, D L; Kim, H M; Calore, B et al. (1995) The Fc gamma RI receptor signals through the activation of hck and MAP kinase. J Immunol 154:4039-47

Durden, D L; Rosen, H; Cooper, J A (1994) Serine/threonine phosphorylation of the gamma-subunit after activation of the high-affinity Fc receptor for immunoglobulin G. Biochem J 299 ( Pt 2):569-77

Durden, D L; Rosen, H; Michel, B R et al. (1994) Protein tyrosine phosphatase inhibitors block myeloid signal transduction through the Fc gamma RI receptor. Exp Cell Res 211:150-62