Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI025899-20
Application #
6959940
Study Section
Special Emphasis Panel (NSS)
Program Officer
Ussery, Michael A
Project Start
1987-09-30
Project End
2011-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
20
Fiscal Year
2006
Total Cost
$503,323
Indirect Cost

  Institution

Name
University of Georgia
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
004315578
City
Athens
State
GA
Country
United States
Zip Code
30602

  Publications

Rawal, Ravindra K; Singh, Uma S; Chavre, Satish N et al. (2013) 2'-Fluoro-6'-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: in vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action. Bioorg Med Chem Lett 23:503-6
Bondada, Lavanya; Detorio, Mervi; Bassit, Leda et al. (2013) Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses. ACS Med Chem Lett 4:747-751
Herman, Brian D; Schinazi, Raymond F; Zhang, Hong-wang et al. (2012) Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3'-azido-2',3'-dideoxyguanosine-5'-triphosphates as adenosine analogs. Nucleic Acids Res 40:381-90
Schinazi, Raymond F; Bassit, Leda; Clayton, Marcia M et al. (2012) Evaluation of single and combination therapies with tenofovir disoproxil fumarate and emtricitabine in vitro and in a robust mouse model supporting high levels of hepatitis B virus replication. Antimicrob Agents Chemother 56:6186-91
Nie, Ting; Detorio, Mervi; Schinazi, Raymond F (2011) Universal profiling of HIV-1 pol for genotypic study and resistance analysis across subtypes. Antivir Ther 16:1267-75
Wang, Jianing; Singh, Uma S; Rawal, Ravindra K et al. (2011) Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants. Bioorg Med Chem Lett 21:6328-31
Zhang, Hong-Wang; Detorio, Mervi; Herman, Brian D et al. (2011) Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides. Eur J Med Chem 46:3832-44
Cho, Jong Hyun; Amblard, Franck; Coats, Steven J et al. (2011) Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection. Tetrahedron 67:5487-5493
Gadthula, Srinivas; Rawal, Ravindra K; Sharon, Ashoke et al. (2011) Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6-diol against hepatitis C virus. Bioorg Med Chem Lett 21:3982-5
Roy, Vincent; Obikhod, Aleksandr; Zhang, Hong-Wang et al. (2011) Synthesis and anti-HIV evaluation of 3'-triazolo nucleosides. Nucleosides Nucleotides Nucleic Acids 30:264-70

Showing the most recent 10 out of 113 publications