Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI028973-14
Application #
6510432
Study Section
Special Emphasis Panel (NSS)
Program Officer
Hackett, Charles J
Project Start
2000-05-01
Project End
2005-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
14
Fiscal Year
2002
Total Cost
$342,222
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Lynch, Lydia; Hogan, Andrew E; Duquette, Danielle et al. (2016) iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metab 24:510-519
Garg, Salil; Brenner, Michael B (2015) RNAi screens of lysosomal trafficking. Methods Cell Biol 126:119-38
Lynch, Lydia; Michelet, Xavier; Zhang, Sai et al. (2015) Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol 16:85-95
Hu, Xinli; Kim, Hyun; Brennan, Patrick J et al. (2013) Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells. Proc Natl Acad Sci U S A 110:19030-5
Brennan, Patrick J; Brigl, Manfred; Brenner, Michael B (2013) Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol 13:101-17
Tatituri, Raju V V; Watts, Gerald F M; Bhowruth, Veemal et al. (2013) Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proc Natl Acad Sci U S A 110:1827-32
León, Luis; Tatituri, Raju V V; Grenha, Rosa et al. (2012) Saposins utilize two strategies for lipid transfer and CD1 antigen presentation. Proc Natl Acad Sci U S A 109:4357-64
King, Irah L; Fortier, Anne; Tighe, Michael et al. (2011) Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner. Nat Immunol 13:44-50
Brigl, Manfred; Tatituri, Raju V V; Watts, Gerald F M et al. (2011) Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med 208:1163-77
Garg, Salil; Sharma, Mahak; Ung, Cindy et al. (2011) Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b. Immunity 35:182-93

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