Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI029549-14
Application #
6695328
Study Section
Special Emphasis Panel (NSS)
Program Officer
Korpela, Jukka K
Project Start
1991-03-01
Project End
2009-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
14
Fiscal Year
2004
Total Cost
$382,500
Indirect Cost
Name
Washington University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Spaulding, Caitlin N; Klein, Roger D; Schreiber 4th, Henry L et al. (2018) Precision antimicrobial therapeutics: the path of least resistance? NPJ Biofilms Microbiomes 4:4
O'Brien, Valerie P; Hannan, Thomas J; Nielsen, Hailyn V et al. (2016) Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections. Microbiol Spectr 4:
Spaulding, Caitlin N; Hultgren, Scott J (2016) Adhesive Pili in UTI Pathogenesis and Drug Development. Pathogens 5:
O'Brien, Valerie P; Hannan, Thomas J; Schaeffer, Anthony J et al. (2015) Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection. Curr Opin Infect Dis 28:97-105
Dang, Hung The; Chorell, Erik; Uvell, Hanna et al. (2014) Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity. Org Biomol Chem 12:1942-56
Volkan, Ender; Kalas, Vasilios; Pinkner, Jerome S et al. (2013) Molecular basis of usher pore gating in Escherichia coli pilus biogenesis. Proc Natl Acad Sci U S A 110:20741-6
Kostakioti, Maria; Hadjifrangiskou, Maria; Hultgren, Scott J (2013) Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. Cold Spring Harb Perspect Med 3:a010306
Geibel, Sebastian; Procko, Erik; Hultgren, Scott J et al. (2013) Structural and energetic basis of folded-protein transport by the FimD usher. Nature 496:243-6
Monack, Denise M; Hultgren, Scott J (2013) The complex interactions of bacterial pathogens and host defenses. Curr Opin Microbiol 16:1-3
Volkan, Ender; Ford, Bradley A; Pinkner, Jerome S et al. (2012) Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine. Proc Natl Acad Sci U S A 109:9563-8

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